Gamma‐Glutamyltransferase Elevation Is Frequent in Patients With COVID‐19: A Clinical Epidemiologic Study

Tuo Shao, Yu Tong, Shushu Lu, Andre J. Jeyarajan, Feifei Su, Jianyi Dai, Jichan Shi, Jianping Huang, Chenchan Hu, Lianpeng Wu, Xianning Dai, Zhimeng Cheng, Jiuliang Yan, Peng Huang, Yanzhang Tian, Shasha Li, Raymond T. Chung, Dong Chen – 11 July 2020 – A newly identified coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which causes the infectious coronavirus disease 2019 (COVID‐19), emerged in December 2019 in Wuhan, Hubei Province, China, and now poses a major threat to global public health.

Self‐Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene

Deepti Abbey, Susannah Elwyn, Nicholas J. Hand, Kiran Musunuru, Daniel J. Rader – 8 July 2020 – Establishment of a physiologically relevant human hepatocyte‐like cell system for in vitro translational research has been hampered by the limited availability of cell models that accurately reflect human biology and the pathophysiology of human disease. Here we report a robust, reproducible, and scalable protocol for the generation of hepatic organoids from human induced pluripotent stem cells (hiPSCs) using short exposure to nonengineered matrices.

Real‐World Effectiveness of Obeticholic Acid in Patients with Primary Biliary Cholangitis

Surain B. Roberts, Marwa Ismail, Gowthami Kanagalingam, Andrew L. Mason, Mark G. Swain, Catherine Vincent, Eric M. Yoshida, Cynthia Tsien, Jennifer A. Flemming, Harry L.A. Janssen, Gideon M. Hirschfield, Bettina E. Hansen, Aliya F. Gulamhusein, the Canadian Network for Autoimmune Liver Disease – 6 July 2020 – Patients with primary biliary cholangitis (PBC) with incomplete response to ursodeoxycholic acid are at risk of disease progression and need additional therapy.

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