Comparison of Clinical Outcomes of Induction Regimens in Patients Undergoing Liver Transplantation for Acute Liver Failure

Chimaobi M. Anugwom, Justin R. Parekh, Christine Hwang, Malcolm MacConmara, William M. Lee, Thomas M. Leventhal – 24 June 2020 – Spontaneous survival rates in acute liver failure (ALF) are vastly improved by liver transplantation (LT). However, the value of induction agents beyond steroids continues to be debated. To understand the potential benefit of different induction regimens in the ALF population, we compared overall survival of recipients undergoing LT in the United States for ALF.

Liver Transplantation in the Time of COVID19: Barriers and Ethical Considerations for Management and Next Steps

Ariel Jaffe, Michael L. Schilsky, Ranjit Deshpande, Ramesh Batra – 23 June 2020 – The recent outbreak of the novel virus severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), which causes the corona virus disease of 2019 (COVID19), has spread globally and affects millions of people. This pandemic has taxed our health care system and disrupted normal operations, even life‐saving procedures, such as liver transplants. During these unprecedented times, providers and patients are imperiled and resources for diagnosis and care may be limited.

Longterm Outcomes of Patients Undergoing Liver Transplantation for Acute‐on‐Chronic Liver Failure

Vinay Sundaram, Nadim Mahmud, Giovanni Perricone, Dev Katarey, Robert J. Wong, Constantine J. Karvellas, Brett E. Fortune, Robert S. Rahimi, Harapriya Maddur, Janice H. Jou, Michael Kriss, Lance L. Stein, Moses Lee, Rajiv Jalan, the Multi‐Organ Dysfunction, Evaluation for Liver Transplantation (MODEL) Consortium – 23 June 2020 – Recent data have demonstrated >80% 1‐year survival probability after liver transplantation (LT) for patients with severe acute‐on‐chronic liver failure (ACLF). However, longterm outcomes and complications are still unknown for this population.

Role of Terlipressin and Albumin for Hepatorenal Syndrome in Liver Transplantation

Pratima Sharma, Kevin Moore, Daniel Ganger, Priya Grewal, Robert S. Brown – 23 June 2020 – Hepatorenal syndrome (HRS) is one of the most ominous complications of portal hypertension in patients with decompensated cirrhosis and ascites. It is associated with very high mortality on the wait list. Liver transplantation (LT) is the most successful therapeutic option for patients with HRS.

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