Machine Perfusions in Liver Transplantation: The Evidence‐Based Position Paper of the Italian Society of Organ and Tissue Transplantation

Davide Ghinolfi, Quirino Lai, Daniele Dondossola, Riccardo De Carlis, Marinella Zanierato, Damiano Patrono, Stefano Baroni, Domenico Bassi, Fabio Ferla, Andrea Lauterio, Chiara Lazzeri, Paolo Magistri, Fabio Melandro, Duilio Pagano, Daniele Pezzati, Matteo Ravaioli, Erion Rreka, Luca Toti, Alberto Zanella, Patrizia Burra, Salvatore Petta, Massimo Rossi, Philippe Dutkowski, Wayel Jassem, Paolo Muiesan, Cristiano Quintini, Markus Selzner, Umberto Cillo – 10 June 2020 – The use of machine perfusion (MP) in liver transplantation (LT) is spreading worldwide.

Coronavirus Disease 2019 in Autoimmune Hepatitis: A Lesson From Immunosuppressed Patients

Alessio Gerussi, Cristina Rigamonti, Chiara Elia, Nora Cazzagon, Annarosa Floreani, Roberta Pozzi, Pietro Pozzoni, Ernesto Claar, Luisa Pasulo, Stefano Fagiuoli, Laura Cristoferi, Marco Carbone, Pietro Invernizzi – 9 June 2020 – Chronic immunosuppression is associated with increased and more severe viral infections. However, little is known about the association between immunosuppression and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection.

Coronavirus Disease 2019 in Autoimmune Hepatitis: A Lesson From Immunosuppressed Patients

Alessio Gerussi, Cristina Rigamonti, Chiara Elia, Nora Cazzagon, Annarosa Floreani, Roberta Pozzi, Pietro Pozzoni, Ernesto Claar, Luisa Pasulo, Stefano Fagiuoli, Laura Cristoferi, Marco Carbone, Pietro Invernizzi – 9 June 2020 – Chronic immunosuppression is associated with increased and more severe viral infections. However, little is known about the association between immunosuppression and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection.

Prophylactic Strategy Against De Novo Hepatitis B Virus Infection for Pediatric Recipients Who Receive Hepatitis B Core Antibody–Positive Liver Grafts

Zhuolun Song, Chong Dong, Xingchu Meng, Chao Sun, Kai Wang, Hong Qin, Chao Han, Yang Yang, Fubo Zhang, Weiping Zheng, Jing Chen, Keran Duan, Bowen Bi, Wei Gao – 8 June 2020 – The goal of this study was to evaluate the efficacy of a perioperative prophylactic strategy against de novo hepatitis B virus (HBV) infection in pediatric liver transplantation (LT) recipients with hepatitis B core antibody (HBcAb)–positive grafts. A total of 482 pediatric recipients transplanted between 2013 and 2017 were enrolled, and 170 recipients received HBcAb‐positive liver grafts.

Glutathione S‐Transferase T1 Mismatch Is a Risk Factor for Chronic Ductopenic Rejection of Liver Allografts

Jose Manuel Sousa, Lydia Barrera, Miguel Angel Gomez‐Bravo, Antonio Nuñez‐Roldan, Isabel Aguilera – 8 June 2020 – The underlying causes of chronic rejection (CR) after liver transplantation (LT) are not completely known. The main aim of this study was to explore the involvement of the minor histocompatibility antigen glutathione S‐transferase T1 (GSTT1) in CR. We retrospectively studied 611 patients who underwent LTs at University Hospital Virgen del Rocío between 2003 and 2016 with a median follow‐up of 7.4 ± 4.2 years. The GSTT1 genotype was determined by polymerase chain reaction.

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