Evolving Up‐regulation of Biliary Fibrosis–Related Extracellular Matrix Molecules After Successful Portoenterostomy

Antti Kyrönlahti, Nimish Godbole, Oyediran Akinrinade, Tea Soini, Iiris Nyholm, Noora Andersson, Maria Hukkinen, Jouko Lohi, David B. Wilson, Marjut Pihlajoki, Mikko P. Pakarinen, Markku Heikinheimo – 8 February 2021 – Successful portoenterostomy (SPE) improves the short‐term outcome of patients with biliary atresia (BA) by relieving cholestasis and extending survival with native liver. Despite SPE, hepatic fibrosis progresses in most patients, leading to cirrhosis and a deterioration of liver function.

Linoleic Acid‐Derived Oxylipins Differentiate Early Stage Alcoholic Hepatitis From Mild Alcohol‐Associated Liver Injury

Dennis Warner, Vatsalya Vatsalya, Kara H. Zirnheld, Jeffrey B. Warner, Josiah E. Hardesty, John C. Umhau, Craig J. McClain, Krishnarao Maddipati, Irina A. Kirpich – 8 February 2021 – Alcohol‐associated liver disease (ALD) is a spectrum of liver disorders ranging from steatosis to steatohepatitis, fibrosis, and cirrhosis. Alcohol‐associated hepatitis (AH) is an acute and often severe form of ALD with substantial morbidity and mortality. The mechanisms and mediators of ALD progression and severity are not well understood, and effective therapeutic options are limited.

High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants

Sujit K. Mohanty, Bryan Donnelly, Haley Temple, Ana Ortiz‐Perez, Sarah Mowery, Inna Lobeck, Phylicia Dupree, Holly M. Poling, Monica McNeal, Reena Mourya, Todd Jenkins, Ruchi Bansal, Jorge Bezerra, Greg Tiao – 7 February 2021

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Angela Lamarca, Alvaro Santos‐Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva, Trine Folseraas, Luca Fabris, Rocio I. R. Macias, Marcin Krawczyk, Marek Krawczyk, Vincenzo Cardinale, Chiara Braconi, Domenico Alvaro, Matthias Evert, Jesus M. Banales, Juan W. Valle – 6 February 2021

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