Genomics and Liver Transplantation: Genomic Biomarkers for the Diagnosis of Acute Cellular Rejection
Taisa J. Kohut, Jose F. Barandiaran, Brendan J. Keating – 7 June 2020 – Acute cellular rejection (ACR) is a common complication in liver transplantation recipients (LTRs), especially within the first 12 months, and it is associated with increased morbidity and mortality. Although abnormalities in standard liver biochemistries may raise the clinical suspicion for ACR, it lacks specificity, and invasive liver biopsies, which are associated with numerous risks, are required for definitive diagnoses.