Comparison of Wait‐List Mortality Between Cholangiocarcinoma and Hepatocellular Carcinoma Liver Transplant Candidates

Ioannis A. Ziogas, Laura A. Hickman, Lea K. Matsuoka, Manhal Izzy, Martin I. Montenovo, Scott A. Rega, Irene D. Feurer, Sophoclis P. Alexopoulos – 31 May 2020 – Despite the divergent disease biology of cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC), wait‐list prioritization is identical for both diagnoses. We compared wait‐list and posttransplant outcomes between CCA and HCC liver transplantation patients with Model for End‐Stage Liver Disease exceptions using Scientific Registry of Transplant Recipients data.

Nicotinamide Adenine Dinucleotide Metabolome Is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol‐Related Liver Disease

Richard Parker, Mark S. Schmidt, Owen Cain, Bridget Gunson, Charles Brenner – 31 May 2020 – Nicotinamide adenine dinucleotide (NAD+) and related coenzymes play critical roles in liver function. Although hepatic alcohol metabolism depresses NAD+, current understanding of the NAD+ metabolome in alcohol‐related liver disease (ArLD) is based on animal models. We used human liver samples to quantify the NAD+ metabolome in ArLD with samples obtained at the time of liver transplantation or resection at University Hospitals Birmingham National Health Service Foundation Trust.

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