Etiology of Liver Steatosis Influences the Severity of Ischemia/Reperfusion Injury and Survival After Liver Transplantation in Rats

Yosuke Miyachi, Shintaro Yagi, Masaaki Hirata, Sena Iwamura, Siyuan Yao, Hisaya Shirai, Shinya Okumura, Taku Iida, Takashi Ito, Ryuji Uozumi, Toshimi Kaido, Shinji Uemoto – 8 June 2020 – Liver steatosis is a leading cause of graft disposal in liver transplantation, though the degree of steatosis is often the single factor determining acceptability of the graft. We investigated how the cause of liver steatosis affects graft function in rat orthotopic liver transplantation (OLT).

Genomics and Liver Transplantation: Genomic Biomarkers for the Diagnosis of Acute Cellular Rejection

Taisa J. Kohut, Jose F. Barandiaran, Brendan J. Keating – 7 June 2020 – Acute cellular rejection (ACR) is a common complication in liver transplantation recipients (LTRs), especially within the first 12 months, and it is associated with increased morbidity and mortality. Although abnormalities in standard liver biochemistries may raise the clinical suspicion for ACR, it lacks specificity, and invasive liver biopsies, which are associated with numerous risks, are required for definitive diagnoses.

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