Bilioenteric Reconstruction Techniques in Pediatric Living Donor Liver Transplantation

Murat Kilic, Can A. Karaca, Cahit Yilmaz, Rasim Farajov, Zaza Iakobadze, Kamil Kilic, Sema Aydogdu – 11 July 2020 – Biliary complications (BCs) are still a major cause of morbidity following liver transplantation despite the advancements in the surgical technique. Although Roux‐en‐Y (RY) hepaticojejunostomy has been the standard technique for years in pediatric patients, there is a limited number of reports on the feasibility of duct‐to‐duct (DD) anastomosis, and those reports have controversial outcomes.

Self‐Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene

Deepti Abbey, Susannah Elwyn, Nicholas J. Hand, Kiran Musunuru, Daniel J. Rader – 8 July 2020 – Establishment of a physiologically relevant human hepatocyte‐like cell system for in vitro translational research has been hampered by the limited availability of cell models that accurately reflect human biology and the pathophysiology of human disease. Here we report a robust, reproducible, and scalable protocol for the generation of hepatic organoids from human induced pluripotent stem cells (hiPSCs) using short exposure to nonengineered matrices.

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