How to Survive COVID‐19 Even If the Vaccine Fails
Andrea D. Branch – 28 July 2020 – Coronavirus disease 2019 (COVID‐19) has created an emergency of epic proportions. While a vaccine may be forthcoming, this is not guaranteed, as discussed herein.
Targeted Inhibition of Purine Metabolism Is Effective in Suppressing Hepatocellular Carcinoma Progression
Yong Chun Chong, Tan Boon Toh, Zhiling Chan, Quy Xiao Xuan Lin, Dexter Kai Hao Thng, Lissa Hooi, Zhaobing Ding, Timothy Shuen, Han Chong Toh, Yock Young Dan, Glenn Kunnath Bonney, Lei Zhou, Pierce Chow, Yulan Wang, Touati Benoukraf, Edward Kai‐Hua Chow, Weiping Han – 27 July 2020 – Tumor‐specific metabolic rewiring, acquired to confer a proliferative and survival advantage over nontransformed cells, represents a renewed focus in cancer therapy development.
Transcriptome Profiling Identifies TIGIT as a Marker of T‐Cell Exhaustion in Liver Cancer
Dmitrij Ostroumov, Steven Duong, Jessica Wingerath, Norman Woller, Michael P. Manns, Kai Timrott, Moritz Kleine, Wolf Ramackers, Stephanie Roessler, Sven Nahnsen, Stefan Czemmel, Oliver Dittrich‐Breiholz, Tobias Eggert, Florian Kühnel, Thomas C. Wirth – 27 July 2020
Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies
Gen‐Sheng Feng, Kaisa L. Hanley, Yan Liang, Xiaoxue Lin – 26 July 2020 – Hepatocellular carcinoma (HCC) is a most deadly malignant disease worldwide, with no effective mechanism‐based therapy available. Therefore, following the “miracle” outcomes seen in a few patients at the advanced stages of melanoma or lung cancer, the immune checkpoint inhibitors (ICIs) immediately entered clinical trials for advanced HCC patients without pre‐clinical studies.
Liver Injury as a Surrogate for Inflammation and Predictor of Outcomes in COVID‐19
Kajali Mishra, Sandra Naffouj, Sarah Gorgis, Hanan Ibrahim, Sonika Gill, Raef Fadel, Abigail Chatfield, Amy Tang, Reena Salgia – 26 July 2020 – Respiratory failure is the most common cause of death in patients with corona virus disease 2019 (COVID‐19). There have been many investigations to determine predictors of bad outcomes in patients with this illness. Liver enzyme elevation has been described in hospitalized patients with severe COVID‐19; however, little is known about the significance of liver injury regarding outcomes.
Liver Injury as a Surrogate for Inflammation and Predictor of Outcomes in COVID‐19
Kajali Mishra, Sandra Naffouj, Sarah Gorgis, Hanan Ibrahim, Sonika Gill, Raef Fadel, Abigail Chatfield, Amy Tang, Reena Salgia – 26 July 2020 – Respiratory failure is the most common cause of death in patients with corona virus disease 2019 (COVID‐19). There have been many investigations to determine predictors of bad outcomes in patients with this illness. Liver enzyme elevation has been described in hospitalized patients with severe COVID‐19; however, little is known about the significance of liver injury regarding outcomes.
Risk Stratification Based on Chronic Liver Failure Consortium Acute Decompensation Score in Patients With Child‐Pugh B Cirrhosis and Acute Variceal Bleeding
Yong Lv, Zhengyu Wang, Kai Li, Qiuhe Wang, Wei Bai, Xulong Yuan, Tianlei Yu, Jing Niu, Zhiping Yang, Xuan Zhu, Jianbo Zhao, Hui Xue, Zaibo Jiang, Yuzheng Zhuge, Chunqing Zhang, Junhui Sun, Pengxu Ding, Weixin Ren, Yingchun Li, Kewei Zhang, Wenguang Zhang, Wengang Guo, Bohan Luo, Xiaomei Li, Jie Yuan, Na Han, Ying Zhu, Chuangye He, Zhanxin Yin, Daiming Fan, Guohong Han – 24 July 2020
Changing Dogma in Donation After Circulatory Death Liver Transplantation? The Role of Microsteatosis and Macrosteatosis in Allografts
Maximilian Joseph Brol, Jonel Trebicka – 24 July 2020
Bilateral Hematothorax Without Hematemesis—An Unusual Presentation of Variceal Bleeding
Maria Paparoupa, Joerg Schrader, Caroline Jung, Olaf Boenisch, Ansgar W. Lohse, Stefan Kluge – 24 July 2020