Loss of Coordinated Neutrophil Responses to the Human Fungal Pathogen, Candida albicans, in Patients With Cirrhosis

Sally A.I. Knooihuizen, Natalie J. Alexander, Alex Hopke, Nicolas Barros, Adam Viens, Allison Scherer, Natalie J. Atallah, Zeina Dagher, Daniel Irimia, Raymond T. Chung, Michael K. Mansour – 4 January 2021 – Neutrophils are the most abundant white blood cell in the body and are key participants in the defense against fungal infections. Fungal infections occur often in patients with cirrhosis and are associated with increased 30‐day and 90‐day mortality.

Effects of Resmetirom on Noninvasive Endpoints in a 36‐Week Phase 2 Active Treatment Extension Study in Patients With NASH

Stephen A. Harrison, Mustafa Bashir, Sam E. Moussa, Kevin McCarty, Juan Pablo Frias, Rebecca Taub, Naim Alkhouri – 3 January 2021 – Resmetirom (MGL‐3196), a selective thyroid hormone receptor‐β agonist, was evaluated in a 36‐week paired liver biopsy study (NCT02912260) in adults with biopsy‐confirmed nonalcoholic steatohepatitis (NASH). The primary endpoint was relative liver fat reduction as assessed by MRI–proton density fat fraction (MRI‐PDFF), and secondary endpoints included histopathology.

Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes

Akihiko Kimura, Tatehiro Kagawa, Hajime Takei, Yoshihiro Maruo, Hiroshi Sakugawa, Takahiro Sasaki, Tsuyoshi Murai, Nakayuki Naritaka, Hajime Takikawa, Hiroshi Nittono – 31 December 2020 – Organic anion transporting polypeptide (OATP) 1B1 (gene, solute carrier organic anion transporter family member 1B1 [SLCO1B1]) and OATP1B3 (SLCO1B3) serve as transporters for hepatic uptake of important endogenous substances and several commonly prescribed drugs. Inactivation of both proteins together causes Rotor syndrome. How this OATP1B1/1B3 defect disturbs bile acid (BA) metabolism is largely unknown.

Subscribe to