A Fibrosis‐Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis

Yevgeniy Gindin, Chuhan Chung, Zhaoshi Jiang, Jing Zhu Zhou, Jun Xu, Andrew N. Billin, Robert P. Myers, Zachary Goodman, Abdolamir Landi, Michael Houghton, Richard M. Green, Cynthia Levy, Kris V. Kowdley, Christopher L. Bowlus, Andrew J. Muir, Michael Trauner – 3 August 2020

Donor‐Transmitted Cancers in Transplanted Livers: Analysis of Clinical Outcomes

Albino Eccher, Ilaria Girolami, Stefano Marletta, Matteo Brunelli, Amedeo Carraro, Umberto Montin, Ugo Boggi, Claudia Mescoli, Luca Novelli, Deborah Malvi, Letizia Lombardini, Massimo Cardillo, Desley Neil, Antonietta D’Errico – 3 August 2020 – The risk of transmission of malignancy from donor to recipient is low. However, this occurrence has dramatic consequences. Many reports of donor‐derived cancers in liver transplant recipients have been published, but they have not been systematically summarized into a lucid and unified analysis.

Clinical Research in Hepatology in the COVID‐19 Pandemic and Post‐Pandemic Era: Challenges and the Need for Innovation

Elizabeth C. Verna, Marina Serper, Jaime Chu, Kathleen Corey, Oren K. Fix, Karen Hoyt, Kimberly A. Page, Rohit Loomba, Ming Li, Gregory T. Everson, Michael W. Fried, Guadalupe Garcia‐Tsao, Norah Terrault, Anna S. Lok, Raymond T. Chung, K. Rajender Reddy – 2 August 2020 – The severe acute respiratory syndrome coronavirus 2 pandemic has drastically altered all facets of clinical care and research.

Clinical Research in Hepatology in the COVID‐19 Pandemic and Post‐Pandemic Era: Challenges and the Need for Innovation

Elizabeth C. Verna, Marina Serper, Jaime Chu, Kathleen Corey, Oren K. Fix, Karen Hoyt, Kimberly A. Page, Rohit Loomba, Ming Li, Gregory T. Everson, Michael W. Fried, Guadalupe Garcia‐Tsao, Norah Terrault, Anna S. Lok, Raymond T. Chung, K. Rajender Reddy – 2 August 2020 – The severe acute respiratory syndrome coronavirus 2 pandemic has drastically altered all facets of clinical care and research.

LPCN 1144 Resolves NAFLD in Hypogonadal Males

Somaya Albhaisi, Kilyoung Kim, Jonathan Baker, Nachiappan Chidambaram, Mahesh V. Patel, Michael Charlton, Arun J. Sanyal – 2 August 2020 – Hypogonadism affects hepatic lipid metabolism and is expected to promote nonalcoholic fatty liver disease (NAFLD). The aims of this study were to determine (1) the prevalence of NAFLD in hypogonadal males and (2) the impact of correction of hypogonadism by LPCN 1144 (Lipocine, Inc., Salt Lake City, UT), an oral testosterone prodrug, on NAFLD in this population.

Health Care Resource Use and Cost Burden of Chronic Kidney Disease in Patients With Chronic Liver Disease: A Real‐World Claims Analysis

Vinod K. Rustgi, You Li, Tina John, Carolyn Catalano, Mohamed I. Elsaid – 2 August 2020 – Chronic Liver Disease (CLD) is associated with an increased risk of chronic kidney disease (CKD). However, the health care burden of CKD in the CLD spectrum is unknown. We aimed to evaluate the health care use and cost burdens associated with CKD in patients with CLD in the United States by using real‐world claims data. We analyzed data from the Truven Health MarketScan Commercial Claims database from 2010 to 2015.

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