Ten‐Eleven Translocation 1 Promotes Malignant Progression of Cholangiocarcinoma With Wild‐Type Isocitrate Dehydrogenase 1

Xuewei Bai, Hongyu Zhang, Yamei Zhou, Katsuya Nagaoka, Jialin Meng, Chengcheng Ji, Dan Liu, Xianghui Dong, Kevin Cao, Joud Mulla, Zhixiang Cheng, William Mueller, Amalia Bay, Grace Hildebrand, Shaolei Lu, Joselynn Wallace, Jack R. Wands, Bei Sun, Chiung‐Kuei Huang – 1 August 2020

The Power of Single‐Cell Analysis for the Study of Liver Pathobiology

Angela L. Chu, Joel D. Schilling, Kevin R. King, Ariel E. Feldstein – 1 August 2020 – Single cell transcriptomics has emerged as a powerful lens through which to study the molecular diversity of complex tissues such as the liver, during health and disease, both in animal models and in humans. The earliest gene expression methods measured bulk tissue RNA, but the results were often confusing because they derived from the combined transcriptomes of many different cell types in unknown proportions.

A Systematic Review of Patient‐Reported Outcomes in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

Hannah P. Kim, Sarah R. Lieber, Michael E. Rogers, Andrew M. Moon, Marci Loiselle, Jennifer Walker, David N. Assis, Ricky Safer, Rachel Gomel, Donna M. Evon – 1 August 2020 – Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are associated with decreased health‐related quality of life and debilitating symptoms. These experiences can be defined as patient‐reported outcome (PRO) concepts and measured using PRO instruments. We identified all PRO concepts and instruments used in the PBC and PSC literature.

Managing Recipient Hepatic Artery Intimal Dissection During Living Donor Liver Transplantation

Shaleen Agarwal, Rajesh Dey, Yuktansh Pandey, Sapana Verma, Subash Gupta – 31 July 2020 – Recipient hepatic artery intimal dissection (HAD) followed by hepatic artery thrombosis (HAT) is a serious complication of liver transplantation. Once this is recognized intraoperatively, the accepted approach is to use an alternative arterial inflow, which may not be possible in all patients. We describe a new classification and technique for the management of HAD during living donor liver transplantation. On the basis of the longitudinal extent of intimal dissection, HAD was classified into 4 types.

A New Approach for Increasing Availability of Liver Grafts and Donor Safety in Living Donor Liver Transplantation: LD‐RAPID Procedure in the Cirrhotic Setting With Hepatocellular Carcinoma

Deniz Balci, Elvan Onur Kirimker, Meltem Bingol Kologlu, Evren Ustuner, Ufuk Utku Goktug, Suheyla Karadag Erkoc, Ali Abbas Yilmaz, Mustafa Kemal Bayar, Alpay Azap, Ramazan Erdem Er, Abdulkadir Dokmeci, Kaan Karayalcin – 31 July 2020

Center Variation in Intention‐to‐Treat Survival Among Patients Listed for Liver Transplant

Allison J. Kwong, Avegail Flores, Giovanna Saracino, Jodi Boutté, Greg McKenna, Giuliano Testa, Ranjeeta Bahirwani, Anji Wall, W. Ray Kim, Göran Klintmalm, James F. Trotter, Sumeet K. Asrani – 29 July 2020 – In the United States, centers performing liver transplant (LT) are primarily evaluated by patient survival within 1 year after LT, but tight clustering of outcomes allows only a narrow window for evaluation of center variation for quality improvement. Alternate measures more relevant to patients and the transplant community are needed.

Subscribe to