A Circular RNA, Cholangiocarcinoma‐Associated Circular RNA 1, Contributes to Cholangiocarcinoma Progression, Induces Angiogenesis, and Disrupts Vascular Endothelial Barriers

Yi Xu, Kaiming Leng, Yue Yao, Pengcheng Kang, Guanqun Liao, Yi Han, Guangjun Shi, Daolin Ji, Peng Huang, Wangyang Zheng, Zhenglong Li, Jinglin Li, Lining Huang, Liang Yu, Yongxu Zhou, Xingming Jiang, Hao Wang, Chunlong Li, Zhilei Su, Sheng Tai, Xiangyu Zhong, Zhidong Wang, Yunfu Cui – 4 August 2020

Functionally Diverse Inflammatory Responses in Peripheral and Liver Monocytes in Alcohol‐Associated Hepatitis

Adam Kim, Annette Bellar, Megan R. McMullen, Xiaoxia Li, Laura E. Nagy – 4 August 2020 – Alcohol‐associated hepatitis (AH) is an acute inflammatory disease in which gut‐microbial byproducts enter circulation and peripheral immune cells infiltrate the liver, leading to nonresolving inflammation and injury. Single‐cell RNA sequencing of peripheral blood mononuclear cells isolated from patients with AH and healthy controls paired with lipopolysaccharide (LPS) challenge revealed how diverse monocyte responses are divided among individual cells and change in disease.

A Fibrosis‐Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis

Yevgeniy Gindin, Chuhan Chung, Zhaoshi Jiang, Jing Zhu Zhou, Jun Xu, Andrew N. Billin, Robert P. Myers, Zachary Goodman, Abdolamir Landi, Michael Houghton, Richard M. Green, Cynthia Levy, Kris V. Kowdley, Christopher L. Bowlus, Andrew J. Muir, Michael Trauner – 3 August 2020

Donor‐Transmitted Cancers in Transplanted Livers: Analysis of Clinical Outcomes

Albino Eccher, Ilaria Girolami, Stefano Marletta, Matteo Brunelli, Amedeo Carraro, Umberto Montin, Ugo Boggi, Claudia Mescoli, Luca Novelli, Deborah Malvi, Letizia Lombardini, Massimo Cardillo, Desley Neil, Antonietta D’Errico – 3 August 2020 – The risk of transmission of malignancy from donor to recipient is low. However, this occurrence has dramatic consequences. Many reports of donor‐derived cancers in liver transplant recipients have been published, but they have not been systematically summarized into a lucid and unified analysis.

Clinical Research in Hepatology in the COVID‐19 Pandemic and Post‐Pandemic Era: Challenges and the Need for Innovation

Elizabeth C. Verna, Marina Serper, Jaime Chu, Kathleen Corey, Oren K. Fix, Karen Hoyt, Kimberly A. Page, Rohit Loomba, Ming Li, Gregory T. Everson, Michael W. Fried, Guadalupe Garcia‐Tsao, Norah Terrault, Anna S. Lok, Raymond T. Chung, K. Rajender Reddy – 2 August 2020 – The severe acute respiratory syndrome coronavirus 2 pandemic has drastically altered all facets of clinical care and research.

Clinical Research in Hepatology in the COVID‐19 Pandemic and Post‐Pandemic Era: Challenges and the Need for Innovation

Elizabeth C. Verna, Marina Serper, Jaime Chu, Kathleen Corey, Oren K. Fix, Karen Hoyt, Kimberly A. Page, Rohit Loomba, Ming Li, Gregory T. Everson, Michael W. Fried, Guadalupe Garcia‐Tsao, Norah Terrault, Anna S. Lok, Raymond T. Chung, K. Rajender Reddy – 2 August 2020 – The severe acute respiratory syndrome coronavirus 2 pandemic has drastically altered all facets of clinical care and research.

Health Care Resource Use and Cost Burden of Chronic Kidney Disease in Patients With Chronic Liver Disease: A Real‐World Claims Analysis

Vinod K. Rustgi, You Li, Tina John, Carolyn Catalano, Mohamed I. Elsaid – 2 August 2020 – Chronic Liver Disease (CLD) is associated with an increased risk of chronic kidney disease (CKD). However, the health care burden of CKD in the CLD spectrum is unknown. We aimed to evaluate the health care use and cost burdens associated with CKD in patients with CLD in the United States by using real‐world claims data. We analyzed data from the Truven Health MarketScan Commercial Claims database from 2010 to 2015.

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