The Role of Metabolic Lipases in the Pathogenesis and Management of Liver Disease
Matteo Tardelli, Francesca Virginia Bruschi, Michael Trauner – 1 April 2020 – Intracellular lipolysis is an enzymatic pathway responsible for the catabolism of triglycerides (TGs) that is complemented by lipophagy as the autophagic breakdown of lipid droplets. The hydrolytic cleavage of TGs generates free fatty acids (FFAs), which can serve as energy substrates, precursors for lipid synthesis, and mediators in cell signaling.