Comprehensive Health‐State Utilities in Contemporary Patients With Cirrhosis

Chelsey Foster, Jad Baki, Samantha Nikirk, Sydni Williams, Neehar D. Parikh, Elliot B. Tapper – 2 April 2020 – Cost‐effectiveness analysis depends on generalizable health‐state utilities. Unfortunately, the available utilities for cirrhosis are dated, may not reflect contemporary patients, and do not capture the impact of cirrhosis symptoms. We aimed to determine health‐state utilities for cirrhosis, using both the standard gamble (SG) and visual analog scale (VAS). We prospectively enrolled 305 patients.

The Role of Metabolic Lipases in the Pathogenesis and Management of Liver Disease

Matteo Tardelli, Francesca Virginia Bruschi, Michael Trauner – 1 April 2020 – Intracellular lipolysis is an enzymatic pathway responsible for the catabolism of triglycerides (TGs) that is complemented by lipophagy as the autophagic breakdown of lipid droplets. The hydrolytic cleavage of TGs generates free fatty acids (FFAs), which can serve as energy substrates, precursors for lipid synthesis, and mediators in cell signaling.

The Role of Metabolic Lipases in the Pathogenesis and Management of Liver Disease

Matteo Tardelli, Francesca Virginia Bruschi, Michael Trauner – 1 April 2020 – Intracellular lipolysis is an enzymatic pathway responsible for the catabolism of triglycerides (TGs) that is complemented by lipophagy as the autophagic breakdown of lipid droplets. The hydrolytic cleavage of TGs generates free fatty acids (FFAs), which can serve as energy substrates, precursors for lipid synthesis, and mediators in cell signaling.

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