Coronavirus disease 2019 and prevalence of chronic liver disease: A meta‐analysis

Alessandro Mantovani, Giorgia Beatrice, Andrea Dalbeni – 4 April 2020 – At present, there is scarce information regarding the global prevalence of chronic liver disease in individuals with coronavirus disease 2019 (COVID‐19) disease, which is becoming a global pandemic. The aim of this study was to assess the overall prevalence of chronic liver disease among patients with COVID‐19 disease by meta‐analysing data in observational studies and to investigate the relationship between liver damage and COVID‐19 disease.

Comprehensive Health‐State Utilities in Contemporary Patients With Cirrhosis

Chelsey Foster, Jad Baki, Samantha Nikirk, Sydni Williams, Neehar D. Parikh, Elliot B. Tapper – 2 April 2020 – Cost‐effectiveness analysis depends on generalizable health‐state utilities. Unfortunately, the available utilities for cirrhosis are dated, may not reflect contemporary patients, and do not capture the impact of cirrhosis symptoms. We aimed to determine health‐state utilities for cirrhosis, using both the standard gamble (SG) and visual analog scale (VAS). We prospectively enrolled 305 patients.

The Role of Metabolic Lipases in the Pathogenesis and Management of Liver Disease

Matteo Tardelli, Francesca Virginia Bruschi, Michael Trauner – 1 April 2020 – Intracellular lipolysis is an enzymatic pathway responsible for the catabolism of triglycerides (TGs) that is complemented by lipophagy as the autophagic breakdown of lipid droplets. The hydrolytic cleavage of TGs generates free fatty acids (FFAs), which can serve as energy substrates, precursors for lipid synthesis, and mediators in cell signaling.

The Role of Metabolic Lipases in the Pathogenesis and Management of Liver Disease

Matteo Tardelli, Francesca Virginia Bruschi, Michael Trauner – 1 April 2020 – Intracellular lipolysis is an enzymatic pathway responsible for the catabolism of triglycerides (TGs) that is complemented by lipophagy as the autophagic breakdown of lipid droplets. The hydrolytic cleavage of TGs generates free fatty acids (FFAs), which can serve as energy substrates, precursors for lipid synthesis, and mediators in cell signaling.

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