COVID‐19 and liver disease
Jian Sun, Alessio Aghemo, Alejandro Forner, Luca Valenti – 6 April 2020
Impact of an Open Access Nationwide Treatment Model on Hepatitis C Virus Antiviral Drug Resistance
Mark W. Douglas, Enoch S.E. Tay, Dao Sen Wang, Adrian T.L. Ong, Caroline Wilson, Amy Phu, Jen Kok, Dominic E. Dwyer, Rowena A. Bull, Andrew R. Lloyd, Tanya L. Applegate, Gregory J. Dore, Anita Y. Howe, Richard Harrigan, Jacob George – 6 April 2020 – Direct acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment, but drug resistance could undermine proposed global elimination targets. Real‐world studies are needed to inform the impact of widespread DAA treatment on antiviral resistance in the community.
Reply
Vincenzo La Mura, Candid Villanueva, Juan G. Abraldes, Jaime Bosch – 4 April 2020
Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis
Tejasav S. Sehrawat, Juan P. Arab, Mengfei Liu, Pouya Amrollahi, Meihua Wan, Jia Fan, Yasuhiko Nakao, Elisa Pose, Amaia Navarro‐Corcuera, Debanjali Dasgupta, Chieh‐Yu Liao, Li He, Amy S. Mauer, Emma Avitabile, Meritxell Ventura‐Cots, Ramon A. Bataller, Arun J. Sanyal, Naga P. Chalasani, Julie K. Heimbach, Kymberly D. Watt, Gregory J. Gores, Pere Gines, Patrick S. Kamath, Douglas A. Simonetto, Tony Y. Hu, Vijay H. Shah, Harmeet Malhi – 4 April 2020
Managing the Symptoms and Complications of Cholestasis
Mark R. Pedersen, Marlyn J. Mayo – 4 April 2020
The Pathophysiology of Cholestasis and Its Relevance to Clinical Practice
Fernanda Q. Onofrio, Gideon M. Hirschfield – 4 April 2020
Immunopathogenesis of Autoimmune Hepatitis
David N. Assis – 4 April 2020
Pediatric Cholestasis: Epidemiology, Genetics, Diagnosis, and Current Management
Saul J. Karpen – 4 April 2020
Nonalcoholic Fatty Liver Disease and Alcoholic Liver Disease are Major Drivers of Liver Mortality in the United States
James M. Paik, Pegah Golabi, Rakesh Biswas, Saleh Alqahtani, Chapy Venkatesan, Zobair M. Younossi – 4 April 2020 – In the United States, chronic viral hepatitis B and C (CHB and CHC), nonalcoholic fatty liver disease (NAFLD), and alcohol‐related liver disease (ALD) are the main causes of liver deaths attributable to hepatocellular carcinoma (HCC) and cirrhosis. Our aim was to assess the changes in the rates of mortality and years of potential life lost (YLL) for HCC and cirrhosis due to different liver diseases.
Bile Composition as a Diagnostic and Prognostic Tool in Liver Transplantation
Isabel M. A. Brüggenwirth, Robert J. Porte, Paulo N. Martins – 4 April 2020 – Bile secretion and composition reflects the functional status of hepatocytes and cholangiocytes. Bile composition can have a role in the assessment of donor grafts before implantation in the recipient. In addition, changes in bile composition after liver transplantation can serve as a diagnostic and prognostic tool to predict posttransplant complications, such as primary nonfunction, acute cellular rejection, or nonanastomotic biliary strictures.