Hepatology Highlights

Kamolyut Lapumnuaypol, Christopher J. Danford, Daryl T.Y. Lau, Joseph F. Pisa, Robert S. Brown, Angel Morales Santiago, Giorgio Roccaro, Amaia Navarro‐Corcuera, Robert E. Schwartz, Enis Kostallari, Nicholas W. Russo, Petra Hirsova, Jessica L. Maiers, Nidhi Jalan‐Sakrikar – 10 April 2020

Hepatology Highlights

Kamolyut Lapumnuaypol, Christopher J. Danford, Daryl T.Y. Lau, Joseph F. Pisa, Robert S. Brown, Angel Morales Santiago, Giorgio Roccaro, Amaia Navarro‐Corcuera, Robert E. Schwartz, Enis Kostallari, Nicholas W. Russo, Petra Hirsova, Jessica L. Maiers, Nidhi Jalan‐Sakrikar – 10 April 2020

Using Artificial Intelligence for Predicting Survival of Individual Grafts in Liver Transplantation: A Systematic Review

Laura R. Wingfield, Carlo Ceresa, Simon Thorogood, Jacques Fleuriot, Simon Knight – 9 April 2020 – The demand for liver transplantation far outstrips the supply of deceased donor organs, and so, listing and allocation decisions aim to maximize utility. Most existing methods for predicting transplant outcomes use basic methods, such as regression modeling, but newer artificial intelligence (AI) techniques have the potential to improve predictive accuracy.

Human Leukocyte Antigen B*14:01 and B*35:01 Are Associated With Trimethoprim‐Sulfamethoxazole Induced Liver Injury

Yi‐Ju Li, Elizabeth J. Phillips, Andrew Dellinger, Paola Nicoletti, Ryan Schutte, Danmeng Li, David A. Ostrov, Robert J. Fontana, Paul B. Watkins, Andrew Stolz, Ann K Daly, Guruprasad P Aithal, Huiman Barnhart, Naga Chalasani, the Drug‐induced Liver Injury Network – 9 April 2020

Ritonavir and Lopinavir Suppress RCE1 and CAAX Rab Proteins Sensitizing the Liver to Organelle Stress and Injury

Atousa Khalatbari, Pratibha Mishra, Hui Han, Yuxin He, Michelle MacVeigh‐Aloni, Cheng Ji – 8 April 2020 – Organelle stress and Liver injuries often occur in human immunodeficiency virus (HIV) infected patients under anti‐HIV therapies, yet few molecular off‐targets of anti‐HIV drugs have been identified in the liver. Here, we found through total RNA sequencing that the transcription of a host protease Ras converting CAAX endopeptidase 1 (RCE1) was altered in HepG2 cells treated with anti‐HIV protease inhibitors, ritonavir and lopinavir.

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