Bile Composition as a Diagnostic and Prognostic Tool in Liver Transplantation

Isabel M. A. Brüggenwirth, Robert J. Porte, Paulo N. Martins – 4 April 2020 – Bile secretion and composition reflects the functional status of hepatocytes and cholangiocytes. Bile composition can have a role in the assessment of donor grafts before implantation in the recipient. In addition, changes in bile composition after liver transplantation can serve as a diagnostic and prognostic tool to predict posttransplant complications, such as primary nonfunction, acute cellular rejection, or nonanastomotic biliary strictures.

Nonalcoholic Fatty Liver Disease and Alcoholic Liver Disease are Major Drivers of Liver Mortality in the United States

James M. Paik, Pegah Golabi, Rakesh Biswas, Saleh Alqahtani, Chapy Venkatesan, Zobair M. Younossi – 4 April 2020 – In the United States, chronic viral hepatitis B and C (CHB and CHC), nonalcoholic fatty liver disease (NAFLD), and alcohol‐related liver disease (ALD) are the main causes of liver deaths attributable to hepatocellular carcinoma (HCC) and cirrhosis. Our aim was to assess the changes in the rates of mortality and years of potential life lost (YLL) for HCC and cirrhosis due to different liver diseases.

Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis

Tejasav S. Sehrawat, Juan P. Arab, Mengfei Liu, Pouya Amrollahi, Meihua Wan, Jia Fan, Yasuhiko Nakao, Elisa Pose, Amaia Navarro‐Corcuera, Debanjali Dasgupta, Chieh‐Yu Liao, Li He, Amy S. Mauer, Emma Avitabile, Meritxell Ventura‐Cots, Ramon A. Bataller, Arun J. Sanyal, Naga P. Chalasani, Julie K. Heimbach, Kymberly D. Watt, Gregory J. Gores, Pere Gines, Patrick S. Kamath, Douglas A. Simonetto, Tony Y. Hu, Vijay H. Shah, Harmeet Malhi – 4 April 2020

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