Acute Hepatitis Is a Prominent Presentation of the Multisystem Inflammatory Syndrome in Children: A Single‐Center Report
Amanda Cantor, Jonathan Miller, Philip Zachariah, Bernardo DaSilva, Kara Margolis, Mercedes Martinez – 18 August 2020
Immunosuppression Withdrawal After Liver Transplantation for Common Variable Immunodeficiency
Olivier Detry, Nicolas Meurisse, François Jouret, Noella Bletard, Jean Delwaide, Michel Moutschen – 18 August 2020
Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes
Paulo Fontes, Junji Komori, Roberto Lopez, Wallis Marsh, Eric Lagasse – 18 August 2020 – Orthotopic liver transplantation continues to be the only effective therapy for patients with end‐stage liver disease. Unfortunately, many of these patients are not considered transplant candidates, lacking effective therapeutic options that would address both the irreversible progression of their hepatic failure and the control of their portal hypertension. In this prospective study, a swine model was exploited to induce subacute liver failure.
Planned Initiation of Venoarterial Extracorporeal Membrane Oxygenation Prior to Liver Transplantation in a Patient With Severe Portopulmonary Hypertension
Andrew S. Barbas, Jacob N. Schroder, Deeplaxmi P. Borle, Arturo Suarez, Nader Abraham, Michael W. Manning, Timothy E. Miller, Carl L. Berg, Terry A. Fortin, Debra L. Sudan, Aparna S. Rege – 16 August 2020
Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate–Activated Protein Kinase, Causing Sarcopenia in Alcohol‐Associated Liver Disease
Gangarao Davuluri, Nicole Welch, Jinendiran Sekar, Mahesha Gangadhariah, Khaled Alsabbagh Alchirazi, Maradumane L. Mohan, Avinash Kumar, Sashi Kant, Samjhana Thapaliya, McKenzie Stine, Megan R. McMullen, Rebecca L. McCullough, George R. Stark, Laura E. Nagy, Sathyamangla V. Naga Prasad, Srinivasan Dasarathy – 16 August 2020
Maintaining Patient Safety and Data Integrity of Nonalcoholic Steatohepatitis Clinical Trials During the Severe Acute Respiratory Syndrome–Coronavirus 2 Pandemic
Naim Alkhouri, Anita Kohli, Rohit Loomba, Stephen A. Harrison – 14 August 2020
Yes‐Associated Protein Is Crucial for Constitutive Androstane Receptor‐Driven Hepatocyte Proliferation But Not for Induction of Drug Metabolism Genes in Mice
Bharat Bhushan, Laura Molina, Kelly Koral, John W. Stoops, Wendy M. Mars, Swati Banerjee, Anne Orr, Shirish Paranjpe, Satdarshan P. Monga, Joseph Locker, George K. Michalopoulos – 13 August 2020
The Commensal Microbe Veillonella as a Marker for Response to an FGF19 Analog in NASH
Rohit Loomba, Lei Ling, Duy M. Dinh, Alex M. DePaoli, Hsiao D. Lieu, Stephen A. Harrison, Arun J. Sanyal – 13 August 2020
Activation of Liver X Receptor α Sensitizes Mice to T‐Cell Mediated Hepatitis
Li Gao, Bin Li, Jingyuan Wang, Danhua Shen, Min Yang, Runzi Sun, Hung‐Chun Tung, Meishu Xu, Songrong Ren, Min Zhang, Da Yang, Binfeng Lu, Hui Wang, Yulan Liu, Wen Xie – 12 August 2020 – Autoimmune hepatitis (AIH) is an inflammatory disease of the liver. Liver X receptors (LXRs), including the α and β isoforms, are previously known for their anti‐inflammatory activities. The goal of this study is to determine whether and how LXR plays a role in AIH.
Serum Sphingosine‐1‐Phosphate Is Decreased in Patients With Acute‐on‐Chronic Liver Failure and Predicts Early Mortality
Victoria T. Mücke, Katharina Maria Schwarzkopf, Dominique Thomas, Marcus M. Mücke, Sabrina Rüschenbaum, Jonel Trebicka, Josef Pfeilschifter, Stefan Zeuzem, Christian M. Lange, Georgios Grammatikos – 12 August 2020 – Sphingosine‐1‐phosphate (S1P) regulates pathophysiological processes, including liver regeneration, vascular tone control, and immune response. In patients with liver cirrhosis, acute deterioration of liver function is associated with high mortality rates.