Lipoprotein‐Like Nanoparticle Carrying Small Interfering RNA Against Spalt‐Like Transcription Factor 4 Effectively Targets Hepatocellular Carcinoma Cells and Decreases Tumor Burden

William Cruz, Huang Huang, Brian Barber, Elisa Pasini, Lili Ding, Gang Zheng, Juan Chen, Mamatha Bhat – 16 March 2020 – Patients with advanced hepatocellular carcinoma (HCC) are often unable to tolerate chemotherapy due to liver dysfunction in the setting of cirrhosis. We investigate high‐density lipoprotein (HDL)‐mimicking peptide phospholipid scaffold (HPPS), which are nanoparticles that capitalize on normal lipoprotein metabolism and transport, as a solution for directed delivery of small interfering RNA (siRNA) cargo into HCC cells.

Molecular Mechanism for Protection Against Liver Failure in Human Yellow Fever Infection

Fernanda de Oliveira Lemos, Andressa França, Antônio Carlos Melo Lima Filho, Rodrigo M. Florentino, Marcone Loiola Santos, Dabny G. Missiaggia, Gisele Olinto Libanio Rodrigues, Felipe Ferraz Dias, Ingredy Beatriz Souza Passos, Mauro M. Teixeira, Antônio Márcio de Faria Andrade, Cristiano Xavier Lima, Paula Vieira Teixeira Vidigal, Vivian Vasconcelos Costa, Matheus Castro Fonseca, Michael H. Nathanson, M. Fatima Leite – 16 March 2020 – Yellow fever (YF) is a viral hemorrhagic fever that typically involves the liver.

Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis

Wei Chen, Aiting Yang, Jidong Jia, Yury V. Popov, Detlef Schuppan, Hong You – 16 March 2020 – The cross‐linking of structural extracellular matrix (ECM) components, especially fibrillar collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis reversal.

Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis

Wei Chen, Aiting Yang, Jidong Jia, Yury V. Popov, Detlef Schuppan, Hong You – 16 March 2020 – The cross‐linking of structural extracellular matrix (ECM) components, especially fibrillar collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis reversal.

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