Interindividual Diversity in Expression of Organic Anion Uptake Transporters in Normal and Cirrhotic Human Liver

Tatsuya Taniguchi, Alana Zanetti‐Yabur, Pijun Wang, Mykhaylo Usyk, Robert D. Burk, Allan W. Wolkoff – 11 March 2020 – The liver plays an essential role in removing endogenous and exogenous compounds from the circulation. This function is mediated by specific transporters, including members of the family of organic anion transport proteins (OATPs) and the Na+‐taurocholate transporting polypeptide (NTCP). In the present study, transporter protein expression was determined in liver samples from patients with cirrhosis or controls without liver disease.

Biology and Clinical Application of Regulatory RNAs in Hepatocellular Carcinoma

Antonio Pea, Nigel B. Jamieson, Chiara Braconi – 11 March 2020 – Most of the human genome consists of DNA genes that are translated into RNAs but not into proteins. These RNA molecules are named noncoding RNAs (ncRNA). While in the past it was thought that ncRNAs would be redundant without relevant functions, it is now well established that ncRNAs identify a class of regulatory molecules that finely tune cell homeostasis and are deregulated in disease states, including hepatocellular carcinoma (HCC).

Hospitalization Before Liver Transplantation Predicts Posttransplant Patient Survival: A Propensity Score–Matched Analysis

Leke Wiering, Robert Öllinger, Jochen Kruppa, Uwe Schoeneberg, Tomasz Dziodzio, Maximillian Jara, Matthias Biebl, Richard Dargie, Nathanael Raschzok, Wenzel Schöning, Dennis Eurich, Moritz Schmelzle, Igor M. Sauer, Johann Pratschke, Paul V. Ritschl – 11 March 2020 – In contrast to donor factors predicting outcomes of liver transplantation (LT), few suitable recipient parameters have been identified. To this end, we performed an in‐depth analysis of hospitalization status and duration prior to LT as a potential risk factor for posttransplant outcome.

LiverLearning®: 2020 Webinar: Prevention and Management of Ascites in Cirrhosis: Controversies and New Approaches

This webinar will review recent important advances in understanding of how to care for patients with cirrhosis and ascites. Specifically, it will discuss how to risk stratify patients for ascites and new strategies for ascites prevention. In addition, it will address evidence-based approaches to the management of ascites among patients who have chronic kidney disease, a challenging and common clinical scenario. We will utilize a live webinar format that will be recorded for on-demand viewing on Liver Learning ® .Scott W. Biggins (Moderator) Dr. Scott W.

SIRT1 Regulates N6‐Methyladenosine RNA Modification in Hepatocarcinogenesis by Inducing RANBP2‐Dependent FTO SUMOylation

Xiaoming Liu, Jianye Liu, Wen Xiao, Qinghai Zeng, Hao Bo, Yuxing Zhu, Lian Gong, Dong He, Xiaowei Xing, Ruhong Li, Ming Zhou, Wei Xiong, Yanhong Zhou, Jianda Zhou, Xiaohui Li, Fei Guo, Canxia Xu, Xiong Chen, Xiaoyan Wang, Fen Wang, Qiang Wang, Ke Cao – 10 March 2020

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