Nonhospice Palliative Care Within the Treatment of End‐Stage Liver Disease

Manisha Verma, Elliot B. Tapper, Amit G. Singal, Victor Navarro – 13 March 2020 – Palliative care (PC) that has evolved from a focus on end‐of‐life care to an expanded form of holistic care at an early stage for patients with serious illnesses and their families is commonly referred to as nonhospice PC (or early PC). Patients with end‐stage liver disease (ESLD) suffer from a high symptom burden and a deteriorated quality of life (QOL), with uncertain prognosis and limited treatment options.

Intestinal Microbiome‐Macrophage Crosstalk Contributes to Cholestatic Liver Disease by Promoting Intestinal Permeability in Mice

Anna Isaacs‐Ten, Marta Echeandia, Mar Moreno‐Gonzalez, Arlaine Brion, Andrew Goldson, Mark Philo, Angela M. Patterson, Aimee Parker, Mikel Galduroz, David Baker, Simon M. Rushbrook, Falk Hildebrand, Naiara Beraza – 13 March 2020

Hepatotoxicity From Immune Checkpoint Inhibitors: A Systematic Review and Management Recommendation

Thoetchai (Bee) Peeraphatdit, Jennifer Wang, Matthew A. Odenwald, Shaomin Hu, John Hart, Michael R. Charlton – 13 March 2020 – Immune checkpoint inhibitors (ICIs) are monoclonal antibodies targeting immune checkpoint molecules. ICIs are an immunotherapy for the treatment of many advanced malignancies. The advent of ICIs has been a major breakthrough in the field of oncology, a fact recognized by the 2018 Nobel Prize in Physiology or Medicine being awarded for the discovery.

Drug‐Induced Liver Injury in GI Practice

Naemat Sandhu, Victor Navarro – 13 March 2020 – Although drug‐induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure in the United States. It is one of the most challenging diagnoses encountered by gastroenterologists. The development of various drug injury networks has played a vital role in expanding our knowledge regarding drug‐related and herbal and dietary supplement–related liver injury.

Hepatotoxicity From Immune Checkpoint Inhibitors: A Systematic Review and Management Recommendation

Thoetchai (Bee) Peeraphatdit, Jennifer Wang, Matthew A. Odenwald, Shaomin Hu, John Hart, Michael R. Charlton – 13 March 2020 – Immune checkpoint inhibitors (ICIs) are monoclonal antibodies targeting immune checkpoint molecules. ICIs are an immunotherapy for the treatment of many advanced malignancies. The advent of ICIs has been a major breakthrough in the field of oncology, a fact recognized by the 2018 Nobel Prize in Physiology or Medicine being awarded for the discovery.

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