Driving Nonalcoholic Steatohepatitis Forward Using the FibroScan Aspartate Aminotransferase Score, But Obey the Traffic Lights
Nabil Noureddin, Naim Alkhouri, Kimberly A. Brown, Mazen Noureddin – 5 August 2020
Differential Impact of Extended Criteria Donors After Brain Death or Circulatory Death in Adult Liver Transplantation
Keval Pandya, Vinay Sastry, Mara T. Panlilio, Terry C. F. Yip, Shirin Salimi, Claire West, Susan Virtue, Mark Wells, Michael Crawford, Carlo Pulitano, Simone I. Strasser, Geoffrey W. McCaughan, Avik Majumdar, Ken Liu – 4 August 2020 – Using grafts from extended criteria donors (ECDs) and donation after circulatory death (DCD) donors is a strategy to address organ shortage in liver transplantation (LT). We studied the characteristics and outcomes of ECD and DCD grafts. We retrospectively studied consecutive adults who underwent deceased donor LT between 2006 and 2019.
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Eduardo A. Rodriguez, Jorge Rakela, Hugo E. Vargas – 4 August 2020
Functionally Diverse Inflammatory Responses in Peripheral and Liver Monocytes in Alcohol‐Associated Hepatitis
Adam Kim, Annette Bellar, Megan R. McMullen, Xiaoxia Li, Laura E. Nagy – 4 August 2020 – Alcohol‐associated hepatitis (AH) is an acute inflammatory disease in which gut‐microbial byproducts enter circulation and peripheral immune cells infiltrate the liver, leading to nonresolving inflammation and injury. Single‐cell RNA sequencing of peripheral blood mononuclear cells isolated from patients with AH and healthy controls paired with lipopolysaccharide (LPS) challenge revealed how diverse monocyte responses are divided among individual cells and change in disease.
Bidirectional Role of NLRP3 During Acute and Chronic Cholestatic Liver Injury
Mick Frissen, Lijun Liao, Kai Markus Schneider, Sonja Djudjaj, Johannes Haybaeck, Alexander Wree, Ulrike Rolle‐Kampczyk, Martin Bergen, Eicke Latz, Peter Boor, Christian Trautwein – 4 August 2020
A Circular RNA, Cholangiocarcinoma‐Associated Circular RNA 1, Contributes to Cholangiocarcinoma Progression, Induces Angiogenesis, and Disrupts Vascular Endothelial Barriers
Yi Xu, Kaiming Leng, Yue Yao, Pengcheng Kang, Guanqun Liao, Yi Han, Guangjun Shi, Daolin Ji, Peng Huang, Wangyang Zheng, Zhenglong Li, Jinglin Li, Lining Huang, Liang Yu, Yongxu Zhou, Xingming Jiang, Hao Wang, Chunlong Li, Zhilei Su, Sheng Tai, Xiangyu Zhong, Zhidong Wang, Yunfu Cui – 4 August 2020
Pleiotropic Roles of Platelets and Neutrophils in Cell Death and Recovery During Acetaminophen Hepatotoxicity
Hartmut Jaeschke, Anup Ramachandran – 4 August 2020
Hepatocellular Carcinoma–Circulating Tumor Cells Expressing PD‐L1 Are Prognostic and Potentially Associated With Response to Checkpoint Inhibitors
Paul Winograd, Shuang Hou, Colin M. Court, Yi‐Te Lee, Pin‐Jung Chen, Yazhen Zhu, Saeed Sadeghi, Richard S. Finn, Pai‐Chi Teng, Jasmin J. Wang, Zhicheng Zhang, Hongtao Liu, Ronald W. Busuttil, James S Tomlinson, Hsian‐Rong Tseng, Vatche G. Agopian – 4 August 2020 – Hepatocellular carcinoma (HCC) is a leading cause of mortality. Checkpoint inhibitors of programmed cell death protein‐1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) have shown great efficacy, but lack biomarkers that predict response.
A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder
Jasmohan S. Bajaj, Edith A. Gavis, Andrew Fagan, James B. Wade, Leroy R. Thacker, Michael Fuchs, Samarth Patel, Brian Davis, Jill Meador, Puneet Puri, Masoumeh Sikaroodi, Patrick M. Gillevet – 4 August 2020
Donor‐Transmitted Cancers in Transplanted Livers: Analysis of Clinical Outcomes
Albino Eccher, Ilaria Girolami, Stefano Marletta, Matteo Brunelli, Amedeo Carraro, Umberto Montin, Ugo Boggi, Claudia Mescoli, Luca Novelli, Deborah Malvi, Letizia Lombardini, Massimo Cardillo, Desley Neil, Antonietta D’Errico – 3 August 2020 – The risk of transmission of malignancy from donor to recipient is low. However, this occurrence has dramatic consequences. Many reports of donor‐derived cancers in liver transplant recipients have been published, but they have not been systematically summarized into a lucid and unified analysis.