Multispectral Imaging Enables Characterization of Intrahepatic Macrophages in Patients With Chronic Liver Disease

Omar A. Saldarriaga, Benjamin Freiberg, Santhoshi Krishnan, Arvind Rao, Jared Burks, Adam L. Booth, Bradley Dye, Netanya Utay, Monique Ferguson, Abdellah Akil, Minkyung Yi, Laura Beretta, Heather L. Stevenson – 3 March 2020 – Intrahepatic macrophages influence the composition of the microenvironment, host immune response to liver injury, and development of fibrosis. Compared with stellate cells, the role of macrophages in the development of fibrosis remains unclear. Multispectral imaging allows detection of multiple markers in situ in human formalin‐fixed, paraffin‐embedded tissue.

Use of Hepatitis C Nucleic Acid Test–Positive Liver Allografts in Hepatitis C Virus Seronegative Recipients

Nadeem Anwar, Tiffany E. Kaiser, Khurram Bari, Michael Schoech, Tayyab S. Diwan, Madison C. Cuffy, Latifa Silski, Ralph C. Quillin, Kamran Safdar, Shimul A. Shah – 3 March 2020 – Because of underutilization of liver allografts, our center previously showed that hepatitis C virus (HCV) antibody–positive/nucleic acid test (NAT)–negative livers when transplanted into HCV nonviremic recipients were safe with a 10% risk of HCV transmission. Herein, we present our single‐center prospective experience of using HCV NAT+ liver allografts transplanted into HCV NAT– recipients.

Physical Function, Physical Activity, and Quality of Life After Liver Transplantation

Michael A. Dunn, Shari S. Rogal, Andres Duarte‐Rojo, Jennifer C. Lai – 3 March 2020 – Robust physical activity after liver transplantation is an important determinant of longterm health, similar in its importance to the value of pretransplant activity for withstanding the immediate stress of transplantation. Although transplantation normally enables rapid recovery of liver synthetic and metabolic functions, the recovery of physical capacity and performance to normal levels is delayed and often incomplete.

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