Binita M. Kamath, Wen Ye, Nathan P. Goodrich, Kathleen M. Loomes, Rene Romero, James E. Heubi, Daniel H. Leung, Nancy B. Spinner, David A. Piccoli, Estella M. Alonso, Stephen L. Guthery, Saul J. Karpen, Cara L. Mack, Jean P. Molleston, Karen F. Murray, Philip Rosenthal, James E. Squires, Jeffrey Teckman, Kasper S. Wang, Richard Thompson, John C. Magee, Ronald J. Sokol, for the Childhood Liver Disease Research Network (ChiLDReN) – 22 January 2020 – Alagille syndrome (ALGS) is an autosomal dominant multisystem disorder with cholestasis as a defining clinical feature.

Neil Mehta – 22 January 2020 – Deciding on specific treatment strategies involves not only tumor stage, performance status, and severity of underlying liver disease, but additional factors such as biomarkers, organ availability, and radiographic tumor response to treatment. In this review, we present hepatocellular carcinoma (HCC) cases to highlight how to determine therapeutic options for HCC in specific scenarios, including resection versus liver transplant, choice of initial local regional treatment, tumor downstaging, and systemic therapies for advanced HCC.

David Wallace, Thomas Cowling, Mark J. McPhail, Sarah E. Brown, Varuna Aluvihare, Abid Suddle, Georg Auzinger, Michael A. Heneghan, Ian A. Rowe, Kate Walker, Nigel Heaton, Jan Meulen, William Bernal – 22 January 2020

Poh Hwa Ooi, Vera C. Mazurak, Kerry Siminoski, Ravi Bhargava, Jason Y. K. Yap, Susan M. Gilmour, Diana R. Mager – 22 January 2020 – Sarcopenia is a muscle disease characterized by reduced skeletal muscle mass (SMM), muscle strength, and physical performance. Reduced SMM has been identified in children after liver transplantation (LT), but no information related to muscle strength/physical performance or lifestyle factors contributing to sarcopenia is available.

21 January 2020

21 January 2020

21 January 2020

21 January 2020

21 January 2020

21 January 2020