Hepatocellular Carcinoma—How to Determine Therapeutic Options

Neil Mehta – 22 January 2020 – Deciding on specific treatment strategies involves not only tumor stage, performance status, and severity of underlying liver disease, but additional factors such as biomarkers, organ availability, and radiographic tumor response to treatment. In this review, we present hepatocellular carcinoma (HCC) cases to highlight how to determine therapeutic options for HCC in specific scenarios, including resection versus liver transplant, choice of initial local regional treatment, tumor downstaging, and systemic therapies for advanced HCC.

Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multicenter Observational Study

Binita M. Kamath, Wen Ye, Nathan P. Goodrich, Kathleen M. Loomes, Rene Romero, James E. Heubi, Daniel H. Leung, Nancy B. Spinner, David A. Piccoli, Estella M. Alonso, Stephen L. Guthery, Saul J. Karpen, Cara L. Mack, Jean P. Molleston, Karen F. Murray, Philip Rosenthal, James E. Squires, Jeffrey Teckman, Kasper S. Wang, Richard Thompson, John C. Magee, Ronald J. Sokol, for the Childhood Liver Disease Research Network (ChiLDReN) – 22 January 2020 – Alagille syndrome (ALGS) is an autosomal dominant multisystem disorder with cholestasis as a defining clinical feature.

Deficits in Muscle Strength and Physical Performance Influence Physical Activity in Sarcopenic Children After Liver Transplantation

Poh Hwa Ooi, Vera C. Mazurak, Kerry Siminoski, Ravi Bhargava, Jason Y. K. Yap, Susan M. Gilmour, Diana R. Mager – 22 January 2020 – Sarcopenia is a muscle disease characterized by reduced skeletal muscle mass (SMM), muscle strength, and physical performance. Reduced SMM has been identified in children after liver transplantation (LT), but no information related to muscle strength/physical performance or lifestyle factors contributing to sarcopenia is available.

Hepatology Highlights

Pir A. Shah, Daryl T.Y. Lau, Nicholas W. Russo, Robert S. Brown, Jessica L. Maiers, Robert E. Schwartz, Norihiro Imai, Tibor I. Krisko, Amaia Navarro‐Corcuera, Nidhi Jalan‐Sakrikar, Joseph F. Pisa, Arun B. Jesudian, Zaid H. Tafesh, Brett E. Fortune, Enis Kostallari – 21 January 2020

Prognostic Factors in Pediatric Early Liver Retransplantation

Isabel Cañon Reyes, Esteban Halac, Diego Aredes, Leandro Lauferman, Guillermo Cervio, Marcelo Dip, Julia Minetto, Hayellen Reijenstein, Veronica Meza, Maria Gole, Agustina Jacobo Dillon, Oscar Imventarza – 21 January 2020 – The most common indications for early liver retransplantation (eRe‐LT) are vascular complications and primary nonfunction (PNF). These patients are usually in a critical clinical condition that can affect their chances of survival. In fact, the survival of these patients is usually lower compared with the patients undergoing a first transplant.

Thirty‐Day Readmission and Cost Analysis in Patients With Cirrhosis: A Nationwide Population‐Based Data

Sakkarin Chirapongsathorn, Kittiyod Poovorawan, Ngamphol Soonthornworasiri, Wirichada Pan‐ngum, Kamthorn Phaosawasdi, Sombat Treeprasertsuk – 21 January 2020 – Accurate population‐based data are needed on the rate, economic impact, and the long‐term outcomes of readmission among patients with cirrhosis.

Subscribe to