Pregnancy in Liver Transplantation

Mussarat N. Rahim, Lisa Long, Leonie Penna, Catherine Williamson, Nikos A. Kametas, Kypros H. Nicolaides, Michael A. Heneghan – 16 January 2020 – Pregnancy after liver transplantation (LT) is increasingly common and is a frequent scenario that transplant physicians, obstetricians, and midwives encounter. This review summarizes the key issues surrounding preconception, pregnancy‐related outcomes, immunosuppression, and breastfeeding in female LT recipients.

Primary Sclerosing Cholangitis With Features of Autoimmune Hepatitis: Exploring the Global Variation in Management

Piotr Milkiewicz, Marcin Krawczyk, Ewa Wunsch, Cyriel Ponsioen, Gideon M. Hirschfield, Stefan G. Hubscher – 16 January 2020 – Patients with primary sclerosing cholangitis (PSC) frequently manifest features of autoimmune hepatitis (AIH). We sought to understand factors affecting expert management, with the goal of facilitating uniformity of care. A Survey Monkey questionnaire with four hypothetical cases suggesting a potential AIH/PSC variant was sent to hepatologists spanning global practices. Eighty responses from clinicians in 23 countries were obtained.

Intraoperative Troponin Elevation in Liver Transplantation Is Independently Associated With Mortality: A Prospective Observational Study

Almudena L. Vilchez‐Monge, Ignacio Garutti, Concepción Jimeno, Matilde Zaballos, Consuelo Jimenez, Luis Olmedilla, Patricia Piñeiro, Patricia Duque, Magdalena Salcedo, Jose M. Asencio, Jose A Lopez‐Baena, Przemyslaw Maruszewski, Rafael Bañares, Jose M. Perez‐Peña – 16 January 2020 – Intraoperative factors implicated in postoperative mortality after liver transplantation (LT) are poorly understood. Because LT is a particularly demanding procedure, we hypothesized that intraoperative myocardial injury may be frequent and independently associated with early postoperative outcomes.

Pregnancy in Liver Transplantation

Mussarat N. Rahim, Lisa Long, Leonie Penna, Catherine Williamson, Nikos A. Kametas, Kypros H. Nicolaides, Michael A. Heneghan – 16 January 2020 – Pregnancy after liver transplantation (LT) is increasingly common and is a frequent scenario that transplant physicians, obstetricians, and midwives encounter. This review summarizes the key issues surrounding preconception, pregnancy‐related outcomes, immunosuppression, and breastfeeding in female LT recipients.

Nursing Care of Patients With Cirrhosis: The LiverHope Nursing Project

Núria Fabrellas, Marta Carol, Ester Palacio, Marites Aban, Tommaso Lanzillotti, Gea Nicolao, Maria Teresa Chiappa, Vanessa Esnault, Sabine Graf‐Dirmeier, Jeltje Helder, Andrea Gossard, Mireia Lopez, Marta Cervera, Lacey L. Dols, the LiverHope Consortium Investigators – 16 January 2020 – Cirrhosis is a complex disease that is associated with disturbances in different organs besides the liver, including kidneys, heart, arterial circulation, lungs, gut, and brain.

Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK

Ana Sandoval‐Rodriguez, Hugo Christian Monroy‐Ramirez, Alejandra Meza‐Rios, Jesus Garcia‐Bañuelos, Jose Vera‐Cruz, Jorge Gutiérrez‐Cuevas, Jorge Silva‐Gomez, Bart Staels, Jose Dominguez‐Rosales, Marina Galicia‐Moreno, Monica Vazquez‐Del Mercado, Jose Navarro‐Partida, Arturo Santos‐Garcia, Juan Armendariz‐Borunda – 16 January 2020 – Nonalcoholic steatohepatitis (NASH) is recognized by hepatic lipid accumulation, inflammation, and fibrosis. No studies have evaluated the prolonged‐release pirfenidone (PR‐PFD) properties on NASH features.

Hepatitis C Virus Prevalence in 50 U.S. States and D.C. by Sex, Birth Cohort, and Race: 2013‐2016

Heather Bradley, Eric W. Hall, Elizabeth M. Rosenthal, Patrick S. Sullivan, A. Blythe Ryerson, Eli S. Rosenberg – 14 January 2020 – Hepatitis C virus (HCV) infection is a leading cause of liver‐related morbidity and mortality, and more than 2 million adults in the United States are estimated to be currently infected. Reducing HCV burden will require an understanding of demographic disparities and targeted efforts to reduce prevalence in populations with disproportionate disease rates. We modeled state‐level estimates of hepatitis C prevalence among U.S.

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