PTPRε Acts as a Metastatic Promoter in Hepatocellular Carcinoma by Facilitating Recruitment of SMAD3 to TGF‐β Receptor 1

Zhibin Liao, Lin Chen, Xuewu Zhang, Hongwei Zhang, Xiaolong Tan, Keshuai Dong, Xun Lu, He Zhu, Qiumeng Liu, Zhanguo Zhang, Zeyang Ding, Wei Dong, Peng Zhu, Liang Chu, Huifang Liang, Pran K. Datta, Bixiang Zhang, Xiaoping Chen – 6 January 2020

The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver‐Homing Receptors on Human Blood CD56bright Natural Killer Cells

Leonard U. Hess, Glòria Martrus, Annerose E. Ziegler, Annika E. Langeneckert, Wilhelm Salzberger, Hanna Goebels, Adrian F. Sagebiel, Sven H. Hagen, Tobias Poch, Gevitha Ravichandran, Martina Koch, Christoph Schramm, Karl J. Oldhafer, Lutz Fischer, Gisa Tiegs, Laura Richert, Madeleine J. Bunders, Sebastian Lunemann, Marcus Altfeld – 6 January 2020 – The transcription factor promyelocytic leukemia zinc finger protein (PLZF) is involved in the development of natural killer (NK) cells and innate lymphoid cells, including liver‐resident NK cells in mice.

Liver Disease in Pregnancy: What's New

Carla W. Brady – 6 January 2020 – Liver disease in pregnancy may present as a disorder that is unique to pregnancy or as an acute or chronic liver disease occurring coincidentally in pregnancy. Hepatic diseases that are unique to pregnancy include hyperemesis gravidarum; preeclampsia/eclampsia; the syndrome of hemolysis, elevated liver enzymes, and low platelets; intrahepatic cholestasis of pregnancy; and acute fatty liver of pregnancy.

Recurrence After Curative Resection of Hepatitis B Virus–Related Hepatocellular Carcinoma: Diagnostic Algorithms on Gadoxetic Acid–Enhanced Magnetic Resonance Imaging

Wentao Wang, Chun Yang, Kai Zhu, Li Yang, Ying Ding, Rongkui Luo, Shuo Zhu, Caizhong Chen, Wei Sun, Mengsu Zeng, Sheng‐Xiang Rao – 4 January 2020 – Small recurrent hepatocellular carcinoma (HCC) can show atypical imaging patterns, and a specific diagnostic algorithm for HCC is lacking. This study aimed to better characterize postoperative recurrent HCCs <20 mm in size with gadoxetic acid–enhanced magnetic resonance imaging (MRI). We evaluated 373 newly developed nodules after hepatectomy in 204 HCC patients with chronic hepatitis B virus infection.

Outcomes of Liver Transplant for Adults With Wilson’s Disease

Alberto Ferrarese, Maria Cristina Morelli, Paola Carrai, Martina Milana, Mario Angelico, Giovanni Perricone, Luca Saverio Belli, Giuseppe Marrone, Antonio Grieco, Silvia Martini, Matteo Angelo Manini, Stefano Fagiuoli, Pierluigi Toniutto, Alfonso Galeota Lanza, Sherrie Bhoori, Salvatore Petta, Edoardo G. Giannini, Patrizia Burra – 4 January 2020 – Wilson’s disease (WD) is a rare genetic disorder with protean manifestations.

Assessment of Rapid Hepatic Glycogen Synthesis in Humans Using Dynamic 13C Magnetic Resonance Spectroscopy

Stefan Stender, Vlad G. Zaha, Craig R. Malloy, Jessica Sudderth, Ralph J. DeBerardinis, Jae Mo Park – 4 January 2020 – Carbon‐13 magnetic resonance spectroscopy (MRS) following oral intake of 13C‐labeled glucose is the gold standard for imaging glycogen metabolism in humans. However, the temporal resolution of previous studies has been >13 minutes. Here, we describe a high‐sensitivity 13C MRS method for imaging hepatic glycogen synthesis with a temporal resolution of 1 minute or less.

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