Modulation of Biliary Cancer Chemo‐Resistance Through MicroRNA‐Mediated Rewiring of the Expansion of CD133+ Cells

Pietro Carotenuto, Somaieh Hedayat, Matteo Fassan, Vincenzo Cardinale, Andrea Lampis, Vincenza Guzzardo, Caterina Vicentini, Aldo Scarpa, Luciano Cascione, Daniele Costantini, Guido Carpino, Domenico Alvaro, Michele Ghidini, Francesco Trevisani, Robert Te Poele, Massimiliano Salati, Sofia Ventura, Georgios Vlachogiannis, Jens C. Hahne, Luke Boulter, Stuart J. Forbes, Rachel V.

Identification of Four Immune Subtypes Characterized by Distinct Composition and Functions of Tumor Microenvironment in Intrahepatic Cholangiocarcinoma

Sylvie Job, Delphine Rapoud, Alexandre Dos Santos, Patrick Gonzalez, Christophe Desterke, Gérard Pascal, Nabila Elarouci, Mira Ayadi, René Adam, Daniel Azoulay, Denis Castaing, Eric Vibert, Daniel Cherqui, Didier Samuel, Antonio Sa Cuhna, Agnès Marchio, Pascal Pineau, Catherine Guettier, Aurélien Reyniès, Jamila Faivre – 25 December 2019

Endogenous Interleukin 18 Suppresses Liver Regeneration After Hepatectomy in Mice

Tao Ma, Yibo Zhang, Mengyi Lao, Wen Chen, Qida Hu, Xiao Zhi, Zhiliang Chen, Xueli Bai, Xiaowei Dang, Tingbo Liang – 24 December 2019 – The comprehensive role of interleukin (IL) 18 during liver regeneration is barely studied. Our aim is to evaluate the role of IL18 in liver regeneration after partial hepatectomy (PH) in mice. The expression profile of IL18 in the liver and the gut after 70% PH was measured. Liver samples after 70% and 85% PH from IL18 knockout (IL18−/−) mice and wild type (WT) mice were collected for comparison of liver regeneration.

Posttransplant Complications Predict Alcohol Relapse in Liver Transplant Recipients

Toshihiro Kitajima, Shunji Nagai, Antu Segal, Michelle Magee, Shaundra Blackburn, Donna Ellithorpe, Siri Yeddula, Yusuf Qadeer, Atsushi Yoshida, Dilip Moonka, Kimberly Brown, Marwan S. Abouljoud – 24 December 2019 – Alcohol relapse after liver transplantation (LT) in patients with alcohol‐related liver disease (ALD) is a major challenge. Although its association with pretransplant psychosocial factors was extensively studied, the impacts of posttransplant courses on alcohol relapse have not been well investigated.

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