Modulation of Biliary Cancer Chemo‐Resistance Through MicroRNA‐Mediated Rewiring of the Expansion of CD133+ Cells

Pietro Carotenuto, Somaieh Hedayat, Matteo Fassan, Vincenzo Cardinale, Andrea Lampis, Vincenza Guzzardo, Caterina Vicentini, Aldo Scarpa, Luciano Cascione, Daniele Costantini, Guido Carpino, Domenico Alvaro, Michele Ghidini, Francesco Trevisani, Robert Te Poele, Massimiliano Salati, Sofia Ventura, Georgios Vlachogiannis, Jens C. Hahne, Luke Boulter, Stuart J. Forbes, Rachel V.

Identification of Four Immune Subtypes Characterized by Distinct Composition and Functions of Tumor Microenvironment in Intrahepatic Cholangiocarcinoma

Sylvie Job, Delphine Rapoud, Alexandre Dos Santos, Patrick Gonzalez, Christophe Desterke, Gérard Pascal, Nabila Elarouci, Mira Ayadi, René Adam, Daniel Azoulay, Denis Castaing, Eric Vibert, Daniel Cherqui, Didier Samuel, Antonio Sa Cuhna, Agnès Marchio, Pascal Pineau, Catherine Guettier, Aurélien Reyniès, Jamila Faivre – 25 December 2019

Endogenous Interleukin 18 Suppresses Liver Regeneration After Hepatectomy in Mice

Tao Ma, Yibo Zhang, Mengyi Lao, Wen Chen, Qida Hu, Xiao Zhi, Zhiliang Chen, Xueli Bai, Xiaowei Dang, Tingbo Liang – 24 December 2019 – The comprehensive role of interleukin (IL) 18 during liver regeneration is barely studied. Our aim is to evaluate the role of IL18 in liver regeneration after partial hepatectomy (PH) in mice. The expression profile of IL18 in the liver and the gut after 70% PH was measured. Liver samples after 70% and 85% PH from IL18 knockout (IL18−/−) mice and wild type (WT) mice were collected for comparison of liver regeneration.

Posttransplant Complications Predict Alcohol Relapse in Liver Transplant Recipients

Toshihiro Kitajima, Shunji Nagai, Antu Segal, Michelle Magee, Shaundra Blackburn, Donna Ellithorpe, Siri Yeddula, Yusuf Qadeer, Atsushi Yoshida, Dilip Moonka, Kimberly Brown, Marwan S. Abouljoud – 24 December 2019 – Alcohol relapse after liver transplantation (LT) in patients with alcohol‐related liver disease (ALD) is a major challenge. Although its association with pretransplant psychosocial factors was extensively studied, the impacts of posttransplant courses on alcohol relapse have not been well investigated.

Cardiac and Liver Disease in Children: Implications for Management Before and After Liver Transplantation

Nicola D. Ruth, Nigel E. Drury, James Bennett, Deirdre A. Kelly – 24 December 2019 – There is close interaction between the functions of the liver and heart affecting the presentation, diagnosis, and outcome of acute and chronic cardiac and liver disease. Conditions affecting both organ systems should be considered when proposing transplantation because the interaction between cardiac disease and liver disease has implications for diagnosis, management, selection for transplantation, and, ultimately, for longterm outcomes after liver transplantation (LT).

Living Donor Liver Transplantation When Deceased Donor Is Not Possible or Timely: Case Examples and Ethical Perspectives

Josh Levitsky, Elisa J. Gordon – 24 December 2019 – This article analyzes the ethical soundness of living donor liver transplantation (LDLT) in situations where the transplant team does not consider deceased donor liver transplantation (DDLT) a clinical or timely option. Given that patients with end‐stage liver disease have a high risk of death without DDLT, the option of LDLT becomes compelling and may save lives.

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