Nicholas Russo, Robert S. Brown, Shawn L. Shah, Tibor I. Krisko, Christopher S. Krumm, Hayley T. Nicholls, Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Zurabi Lominadze, Russell Rosenblatt, Brett E. Fortune, Joseph F. Pisa, Arun B. Jesudian, Vikas Gupta, Zaid H. Tafesh – 29 January 2019
29 January 2019
29 January 2019
Nicholas Russo, Robert S. Brown, Shawn L. Shah, Tibor I. Krisko, Christopher S. Krumm, Hayley T. Nicholls, Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Zurabi Lominadze, Russell Rosenblatt, Brett E. Fortune, Joseph F. Pisa, Arun B. Jesudian, Vikas Gupta, Zaid H. Tafesh – 29 January 2019
Jonathan Fryer – 29 January 2019
Donghwan Kim, Chad N. Brocker, Shogo Takahashi, Tomoki Yagai, Taehyeong Kim, Guomin Xie, Hua Wang, Aijuan Qu, Frank J. Gonzalez – 29 January 2019 – Chronic activation of the nuclear receptor peroxisome proliferator–activated receptor alpha (PPARA) promotes MYC‐linked hepatocellular carcinoma (HCC) in mice. Recent studies have shown that MYC can function as an amplifier of transcription where MYC does not act as an “on‐off” switch for gene expression but rather accelerates transcription rates at active promoters by stimulating transcript elongation.
Sergio Anastasi – 29 January 2019
A. Jay Freeman, Zachary M. Sellers, George Mazariegos, Andrea Kelly, Lisa Saiman, George Mallory, Simon C. Ling, Michael R. Narkewicz, Daniel H. Leung – 29 January 2019 – Approximately 5%‐10% of patients with cystic fibrosis (CF) will develop advanced liver disease with portal hypertension, representing the third leading cause of death among patients with CF. Cystic fibrosis with advanced liver disease and portal hypertension (CFLD) represents the most significant risk to patient mortality, second only to pulmonary or lung transplant complications in patients with CF.
François Durand, Corinne Antoine, Olivier Soubrane – 29 January 2019 – In France, the main indications for liver transplantation are hepatocellular carcinoma (HCC) and alcoholic cirrhosis. The number of candidates for decompensated hepatitis C virus–related cirrhosis has markedly decreased since the advent of direct‐acting antiviral agents. Nonalcoholic steatohepatitis represents a lower proportion of candidates as compared with the United States.
Nicolas Weiss, Dominique Thabut – 29 January 2019 – Orthotopic liver transplantation (LT) remains the only way to definitively cure patients with the most severe liver diseases. Because the survival rate is now fairly high, important questions about neurological sequelae or quality of life after LT have emerged. Indeed, LT represents a peculiar situation because up to 30% of patients present with neurological symptoms after LT compared with only 4% after cardiac transplant and 0.5% after renal transplant.