Hepatic artery occlusion in liver transplantation: What counts more, the type of reconstruction or the severity of the recipient's disease?

Christian E. Oberkofler, Tim Reese, Dimitri A. Raptis, Christoph Kuemmerli, Olivier de Rougemont, Michelle L. De Oliveira, Andrea Schlegel, Philipp Dutkowski, Pierre‐Alain Clavien, Henrik Petrowsky – 1 March 2018 – Although the type of hepatic artery revascularization technique is known to have an impact on patency rates, independent perioperative risk factors on patient outcomes are poorly defined. All consecutive adult patients undergoing cadaveric liver transplantation (n = 361) from July 2007 to June 2016 in a single institution were analyzed.

Combined Dual‐Kidney Liver Transplantation in the United States: A Review of United Network for Organ Sharing/Organ Procurement and Transplantation Network Data Between 2002 and 2012

Grigoriy Shekhtman, Edmund Huang, Gabriel M. Danovitch, Paul Martin, Suphamai Bunnapradist – 1 March 2018 – In kidney‐alone recipients, dual‐kidney transplantation using “higher‐risk” donor organs has shown outcomes comparable to those of single‐kidney transplantation using extended criteria donor (ECD) organs.

Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment

Lucy Golden‐Mason, Rachel H. McMahan, Michael S. Kriss, Alexandra L. Kilgore, Linling Cheng, Rachael J. Dran, Amanda Wieland, Hugo R. Rosen – 1 March 2018 – Chronic hepatitis C virus (HCV) infection is characterized by dysregulated natural killer (NK) cell responses. NKs play a critical role in achieving sustained responses to interferon (IFN)‐α‐based therapy. Rapid sustained HCV‐RNA clearance is now achieved with direct‐acting antivirals (DAAs). Studies of patients receiving first‐wave DAAs suggest NK functional restoration.

The Role of Intestinal C‐type Regenerating Islet Derived‐3 Lectins for Nonalcoholic Steatohepatitis

Sena Bluemel, Lirui Wang, Cameron Martino, Suhan Lee, Yanhan Wang, Brandon Williams, Angela Horvath, Vanessa Stadlbauer, Karsten Zengler, Bernd Schnabl – 28 February 2018 – C‐type regenerating islet derived‐3 (Reg3) lectins defend against pathogens and keep commensal bacteria at a distance. Deficiency of Reg3g and Reg3b facilitates alcohol‐induced bacterial translocation and alcoholic liver disease. Intestinal Reg3g is down‐regulated in animal models of diet‐induced obesity, but the functional consequences for nonalcoholic steatohepatitis (NASH) are unknown.

Hilar cholangiocarcinoma associated with immunoglobulin G4‐positive plasma cells and elevated serum immunoglobulin G4 levels

Nabeel Azeem, Veeral Ajmera, Bilal Hameed, Neil Mehta – 28 February 2018 – Immunoglobulin G4 (IgG4)‐related disease is a fibroinflammatory systemic disorder with multiorgan involvement. Proximal bile duct involvement results in IgG4‐related sclerosing cholangitis, which is characterized by a lymphoplasmacytic infiltrate with abundant IgG4‐positive plasma cells and fibrosis. Differentiating between cholangiocarcinoma and IgG4‐sclerosing cholangitis can present a diagnostic dilemma.

Pure Laparoscopic Living Donor Left Lateral Sectionectomy in Pediatric Transplantation: A Propensity Score Analysis on 220 Consecutive Patients

Dieter C. Broering, Yasser Elsheikh, Mohammed Shagrani, Faisal Abaalkhail, Roberto I. Troisi – 28 February 2018 – Left lateral sectionectomy for donor hepatectomy is a well‐established alternative to deceased donor pediatric liver transplantation. However, very little is available on the laparoscopic approach (laparoscopic left lateral sectionectomy [L‐LLS]).

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