Preeti Pathak, Cen Xie, Robert G. Nichols, Jessica M. Ferrell, Shannon Boehme, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, John Y.L. Chiang – 27 February 2018 – Bile acids activate farnesoid X receptor (FXR) and G protein–coupled bile acid receptor‐1 (aka Takeda G protein–coupled receptor‐5 [TGR5]) to regulate bile acid metabolism and glucose and insulin sensitivity. FXR and TGR5 are coexpressed in the enteroendocrine L cells, but their roles in integrated regulation of metabolism are not completely understood.

Jia‐Feng Wu, Chee‐Seng Lee, Wen‐Hsi Lin, Yung‐Ming Jeng, Huey‐Ling Chen, Yen‐Hsuan Ni, Hong‐Yuan Hsu, Mei‐Hwei Chang – 27 February 2018 – We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA. Forty‐eight cholestatic infants (9‐87 days of age) with direct bilirubin level >1 mg/dL were enrolled. Liver stiffness measurement (LSM) by TE was performed during the cholestasis workup, and 15 subjects were diagnosed as BA.

Wouter Moest, Wendy van der Deure, Ted Koster, Marcela Spee‐Dropková, Linda Swart‐Busscher, Robbert J. de Haas, Terry G.J. Derks – 27 February 2018

Yao‐Yao Zhou, Xiao‐Dong Zhou, Sheng‐Jie Wu, Dan‐Hong Fan, Sven Poucke, Yong‐Ping Chen, Shen‐Wen Fu, Ming‐Hua Zheng – 26 February 2018 – Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of atherosclerotic cardiovascular disease. In our meta‐analysis, we aimed to assess the correlation of NAFLD and four surrogate markers of subclinical atherosclerosis. PubMed, Embase, and the Cochrane Library were searched up until April 2017. Original studies investigating the association between NAFLD and subclinical atherosclerosis were included.

Russell Rosenblatt, Robert S. Brown, Saurabh Mukewar, Yecheskel Schneider, Robert E. Schwartz, Shirley Cohen‐Mekelburg, Clara Tow, Aleksey Novikov, Nicholas Russo, Zaid H. Tafesh, Vikas Gupta – 26 February 2018

26 February 2018

26 February 2018

Russell Rosenblatt, Robert S. Brown, Saurabh Mukewar, Yecheskel Schneider, Robert E. Schwartz, Shirley Cohen‐Mekelburg, Clara Tow, Aleksey Novikov, Nicholas Russo, Zaid H. Tafesh, Vikas Gupta – 26 February 2018

26 February 2018

Hannah C. Jeffery, Manjit K. Braitch, Chris Bagnall, James Hodson, Louisa E. Jeffery, Rebecca E. Wawman, Lin Lee Wong, Jane Birtwistle, Helen Bartlett, Ansgar W. Lohse, Gideon M. Hirschfield, Jessica Dyson, David Jones, Stefan G. Hubscher, Paul Klenerman, David H. Adams, Ye H. Oo – 26 February 2018 – Autoimmune hepatitis (AIH) is an immune‐mediated liver disease currently treated by immunosuppressive medications with significant side effects. Thus, novel mechanistic treatments are greatly needed.