Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment
Lucy Golden‐Mason, Rachel H. McMahan, Michael S. Kriss, Alexandra L. Kilgore, Linling Cheng, Rachael J. Dran, Amanda Wieland, Hugo R. Rosen – 1 March 2018 – Chronic hepatitis C virus (HCV) infection is characterized by dysregulated natural killer (NK) cell responses. NKs play a critical role in achieving sustained responses to interferon (IFN)‐α‐based therapy. Rapid sustained HCV‐RNA clearance is now achieved with direct‐acting antivirals (DAAs). Studies of patients receiving first‐wave DAAs suggest NK functional restoration.