Ashley Cast, Leila Valanejad, Mary Wright, Phuong Nguyen, Anita Gupta, Liqin Zhu, Soona Shin, Nikolai Timchenko – 21 November 2017 – Recent publications show that classic hepatoblastoma (HBL) is the result of failure of hepatic stem cells to differentiate into hepatocytes, while hepatocellular carcinoma (HCC) is caused by the dedifferentiation of hepatocytes into cancer stem cells. However, the mechanisms of aggressive HBL and the mechanisms that cause dedifferentiation of hepatocytes into cancer stem cells are unknown.

Kristjan T. Örnolfsson, Sigurdur Olafsson, Ottar M. Bergmann, M. Eric Gershwin, Einar S. Björnsson – 21 November 2017 – Hereditary factors in primary biliary cholangitis (PBC) have been well defined in genome‐wide association studies, but there are few direct data available that define the relative risk (RR) for family members with an affected proband. An increased risk in first‐degree relatives has been demonstrated in a variety of studies, but data have been lacking on further detailed associations for subsequent generations.

Kristjan T. Örnolfsson, Sigurdur Olafsson, Ottar M. Bergmann, M. Eric Gershwin, Einar S. Björnsson – 21 November 2017 – Hereditary factors in primary biliary cholangitis (PBC) have been well defined in genome‐wide association studies, but there are few direct data available that define the relative risk (RR) for family members with an affected proband. An increased risk in first‐degree relatives has been demonstrated in a variety of studies, but data have been lacking on further detailed associations for subsequent generations.

Takashi Kokudo, Kiyoshi Hasegawa, Norihiro Kokudo – 21 November 2017

Phillipp Hartmann, Katrin Hochrath, Angela Horvath, Peng Chen, Caroline T. Seebauer, Cristina Llorente, Lirui Wang, Yazen Alnouti, Derrick E. Fouts, Peter Stärkel, Rohit Loomba, Sally Coulter, Christopher Liddle, Ruth T. Yu, Lei Ling, Stephen J. Rossi, Alex M. DePaoli, Michael Downes, Ronald M. Evans, David A. Brenner, Bernd Schnabl – 21 November 2017 – Alcoholic liver disease (ALD) is associated with changes in the intestinal microbiota. Functional consequences of alcohol‐associated dysbiosis are largely unknown.

Phillipp Hartmann, Katrin Hochrath, Angela Horvath, Peng Chen, Caroline T. Seebauer, Cristina Llorente, Lirui Wang, Yazen Alnouti, Derrick E. Fouts, Peter Stärkel, Rohit Loomba, Sally Coulter, Christopher Liddle, Ruth T. Yu, Lei Ling, Stephen J. Rossi, Alex M. DePaoli, Michael Downes, Ronald M. Evans, David A. Brenner, Bernd Schnabl – 21 November 2017 – Alcoholic liver disease (ALD) is associated with changes in the intestinal microbiota. Functional consequences of alcohol‐associated dysbiosis are largely unknown.

Elizabeth C. Verna, David S. Goldberg – 21 November 2017

Bruce Wang, Manisha Balwani, Herbert L. Bonkovsky, Karl E. Anderson, Joseph R. Bloomer, D. Montgomery Bissell, John D. Phillips, Robert J. Desnick, For the Porphyrias Consortium of the Rare Diseases Clinical Research Network – 21 November 2017

Edoardo Giovanni Giannini, Laura Bucci, Francesca Garuti, Matteo Brunacci, Barbara Lenzi, Matteo Valente, Eugenio Caturelli, Giuseppe Cabibbo, Fabio Piscaglia, Roberto Virdone, Martina Felder, Francesca Ciccarese, Francesco Giuseppe Foschi, Rodolfo Sacco, Gianluca Svegliati Baroni, Fabio Farinati, Gian Lodovico Rapaccini, Andrea Olivani, Antonio Gasbarrini, Maria Di Marco, Filomena Morisco, Marco Zoli, Alberto Masotto, Franco Borzio, Luisa Benvegnù, Fabio Marra, Antonio Colecchia, Gerardo Nardone, Mauro Bernardi, Franco Trevisani, for the Italian Liver Cancer (ITA.LI.CA) group – 21 November

20 November 2017