Quantitative assessment of liver fibrosis reveals a nonlinear association with fibrosis stage in nonalcoholic fatty liver disease

Yohei Masugi, Tokiya Abe, Hanako Tsujikawa, Kathryn Effendi, Akinori Hashiguchi, Masanori Abe, Yasuharu Imai, Keisuke Hino, Shuhei Hige, Miwa Kawanaka, Gotaro Yamada, Masayoshi Kage, Masaaki Korenaga, Yoichi Hiasa, Masashi Mizokami, Michiie Sakamoto – 27 November 2017 – Accurate staging of liver fibrosis is crucial to guide therapeutic decisions for patients with nonalcoholic fatty liver disease (NAFLD). Digital image analysis has emerged as a promising tool for quantitative assessment of fibrosis in chronic liver diseases.

Acute acalculous cholecystitis during zika virus infection in an immunocompromised patient

Suzane Kioko Ono, Leda Bassit, Victor Van Vaisberg, Venâncio Avancini Ferreira Alves, Elia G. Caldini, Brian D. Herman, Reed Shabman, Nadia B. Fedorova, Denise Paranaguá‐Vezozzo, Caroline Torres Sampaio, Rafael Bandeira Lages, Débora Terrabuio, Wellington Andraus, Raymond F. Schinazi, Flair José Carrilho – 24 November 2017

RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

Mengnuo Chen, Lai Wei, Cheuk‐Ting Law, Felice Ho‐Ching Tsang, Jialing Shen, Carol Lai‐Hung Cheng, Long‐Hin Tsang, Daniel Wai‐Hung Ho, David Kung‐Chun Chiu, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Irene Oi‐Lin Ng, Chun‐Ming Wong – 24 November 2017 – Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epigenetic regulation.

Acute acalculous cholecystitis during zika virus infection in an immunocompromised patient

Suzane Kioko Ono, Leda Bassit, Victor Van Vaisberg, Venâncio Avancini Ferreira Alves, Elia G. Caldini, Brian D. Herman, Reed Shabman, Nadia B. Fedorova, Denise Paranaguá‐Vezozzo, Caroline Torres Sampaio, Rafael Bandeira Lages, Débora Terrabuio, Wellington Andraus, Raymond F. Schinazi, Flair José Carrilho – 24 November 2017

Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial

Julie Thompson, Natasha Jones, Ali Al‐Khafaji, Shahid Malik, David Reich, Santiago Munoz, Ross MacNicholas, Tarek Hassanein, Lewis Teperman, Lance Stein, Andrés Duarte‐Rojo, Raza Malik, Talal Adhami, Sumeet Asrani, Nikunj Shah, Paul Gaglio, Anupama Duddempudi, Brian Borg, Rajiv Jalan, Robert Brown, Heather Patton, Rohit Satoskar, Simona Rossi, Amay Parikh, Ahmed ElSharkawy, Parvez Mantry, Linda Sher, David Wolf, Marquis Hart, Charles Landis, Alan Wigg, Shahid Habib, Geoffrey McCaughan, Steven Colquhoun, Alyssa Henry, Patricia Bedard, Lee Landeen, Michael Millis, Robert Ashley, William Frank

Hypoxia‐inducible factor‐1α/interleukin‐1β signaling enhances hepatoma epithelial–mesenchymal transition through macrophages in a hypoxic‐inflammatory microenvironment

Jingying Zhang, Qi Zhang, Yu Lou, Qihan Fu, Qi Chen, Tao Wei, Jiaqi Yang, Jinlong Tang, Jianxin Wang, Yiwen Chen, Xiaoyu Zhang, Jian Zhang, Xueli Bai, Tingbo Liang – 23 November 2017 – The development and progression of hepatocellular carcinoma (HCC) are dependent on its local microenvironment. Hypoxia and inflammation are two critical factors that shape the HCC microenvironment; however, the interplay between the two factors and the involvement of cancer cells under such conditions remain poorly understood.

Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer

Andrija Matak, Pooja Lahiri, Ethan Ford, Daniela Pabst, Karl Kashofer, Dimitris Stellas, Dimitris Thanos, Kurt Zatloukal – 23 November 2017 – Intratumor heterogeneity is increasingly recognized as a major factor impacting diagnosis and personalized treatment of cancer. We characterized stochastic phenotype switching as a mechanism contributing to intratumor heterogeneity and malignant potential of liver cancer.

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