Toward the elimination of hepatitis C in the United States

Sammy Saab, Long Le, Satvir Saggi, Vinay Sundaram, Myron J. Tong – 27 November 2017 – The emergence of effective direct‐acting antiviral (DAA) agents has reignited discussion over the potential for hepatitis C elimination in the United States. Eliminating hepatitis C will require a critical examination of technical feasibility, economic considerations, and social/political attention. Tremendous advancement has been made with the availability of sensitive diagnostic tests and highly effective DAAs capable of achieving sustained viral response (SVR) in more than 95% of patients.

Toward the elimination of hepatitis C in the United States

Sammy Saab, Long Le, Satvir Saggi, Vinay Sundaram, Myron J. Tong – 27 November 2017 – The emergence of effective direct‐acting antiviral (DAA) agents has reignited discussion over the potential for hepatitis C elimination in the United States. Eliminating hepatitis C will require a critical examination of technical feasibility, economic considerations, and social/political attention. Tremendous advancement has been made with the availability of sensitive diagnostic tests and highly effective DAAs capable of achieving sustained viral response (SVR) in more than 95% of patients.

Quantitative assessment of liver fibrosis reveals a nonlinear association with fibrosis stage in nonalcoholic fatty liver disease

Yohei Masugi, Tokiya Abe, Hanako Tsujikawa, Kathryn Effendi, Akinori Hashiguchi, Masanori Abe, Yasuharu Imai, Keisuke Hino, Shuhei Hige, Miwa Kawanaka, Gotaro Yamada, Masayoshi Kage, Masaaki Korenaga, Yoichi Hiasa, Masashi Mizokami, Michiie Sakamoto – 27 November 2017 – Accurate staging of liver fibrosis is crucial to guide therapeutic decisions for patients with nonalcoholic fatty liver disease (NAFLD). Digital image analysis has emerged as a promising tool for quantitative assessment of fibrosis in chronic liver diseases.

Acute acalculous cholecystitis during zika virus infection in an immunocompromised patient

Suzane Kioko Ono, Leda Bassit, Victor Van Vaisberg, Venâncio Avancini Ferreira Alves, Elia G. Caldini, Brian D. Herman, Reed Shabman, Nadia B. Fedorova, Denise Paranaguá‐Vezozzo, Caroline Torres Sampaio, Rafael Bandeira Lages, Débora Terrabuio, Wellington Andraus, Raymond F. Schinazi, Flair José Carrilho – 24 November 2017

RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

Mengnuo Chen, Lai Wei, Cheuk‐Ting Law, Felice Ho‐Ching Tsang, Jialing Shen, Carol Lai‐Hung Cheng, Long‐Hin Tsang, Daniel Wai‐Hung Ho, David Kung‐Chun Chiu, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Irene Oi‐Lin Ng, Chun‐Ming Wong – 24 November 2017 – Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epigenetic regulation.

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