Kristjan T. Örnolfsson, Sigurdur Olafsson, Ottar M. Bergmann, M. Eric Gershwin, Einar S. Björnsson – 21 November 2017 – Hereditary factors in primary biliary cholangitis (PBC) have been well defined in genome‐wide association studies, but there are few direct data available that define the relative risk (RR) for family members with an affected proband. An increased risk in first‐degree relatives has been demonstrated in a variety of studies, but data have been lacking on further detailed associations for subsequent generations.

Ashley Cast, Leila Valanejad, Mary Wright, Phuong Nguyen, Anita Gupta, Liqin Zhu, Soona Shin, Nikolai Timchenko – 21 November 2017 – Recent publications show that classic hepatoblastoma (HBL) is the result of failure of hepatic stem cells to differentiate into hepatocytes, while hepatocellular carcinoma (HCC) is caused by the dedifferentiation of hepatocytes into cancer stem cells. However, the mechanisms of aggressive HBL and the mechanisms that cause dedifferentiation of hepatocytes into cancer stem cells are unknown.

Edoardo Giovanni Giannini, Laura Bucci, Francesca Garuti, Matteo Brunacci, Barbara Lenzi, Matteo Valente, Eugenio Caturelli, Giuseppe Cabibbo, Fabio Piscaglia, Roberto Virdone, Martina Felder, Francesca Ciccarese, Francesco Giuseppe Foschi, Rodolfo Sacco, Gianluca Svegliati Baroni, Fabio Farinati, Gian Lodovico Rapaccini, Andrea Olivani, Antonio Gasbarrini, Maria Di Marco, Filomena Morisco, Marco Zoli, Alberto Masotto, Franco Borzio, Luisa Benvegnù, Fabio Marra, Antonio Colecchia, Gerardo Nardone, Mauro Bernardi, Franco Trevisani, for the Italian Liver Cancer (ITA.LI.CA) group – 21 November

Clara Tow, Robert S. Brown, Zaid Husni Tafesh, Robert E. Schwartz, Russell Rosenblatt, Shawn L. Shah, Nicole T. Shen, Aleksey Novikov, Shirley Cohen‐Mekelburg, Nicholas Russo, Vikas Gupta – 20 November 2017

Lin Wang – 20 November 2017

Yan Liang, Yun Feng, Min Zong, Xu‐Fu Wei, Jin Lee, Yukuan Feng, Hairi Li, Guang‐Shun Yang, Zhong‐Jun Wu, Xiang‐Dong Fu, Gen‐Sheng Feng – 20 November 2017 – Both activating and inactivating mutations in catenin β1 (ctnnb1), which encodes β‐catenin, have been implicated in liver tumorigenesis in humans and mice, although the underlying mechanisms are not fully understood.

Chetan Kalal, Akash Shukla, Ravi Mohanka, Mihir Vora, Priyesh Patel, Samir Shah – 20 November 2017

Shan Wan, Anne‐Sophie Meyer, Sofia Maria Elisabeth Weiler, Christian Rupp, Marcell Tóth, Carsten Sticht, Stephan Singer, Stefan Thomann, Stephanie Roessler, Marina Schorpp‐Kistner, Jennifer Schmitt, Norbert Gretz, Peter Angel, Darjus Felix Tschaharganeh, Jens Marquardt, Peter Schirmacher, Federico Pinna, Kai Breuhahn – 20 November 2017 – The loss of epithelial cell polarity plays an important role in the development and progression of liver cancer. However, the specific molecular mechanisms supporting tumor initiation and progression are poorly understood.

20 November 2017

Zobair M. Younossi, Arian Afendy, Maria Stepanova, Andrei Racila, Fatema Nader, Rachel Gomel, Ricky Safer, William R. Lenderking, Anne Skalicky, Leah Kleinman, Robert P. Myers, G. Mani Subramanian, John G. McHutchison, Cynthia Levy, Christopher L. Bowlus, Kris Kowdley, Andrew J. Muir – 20 November 2017 – Primary sclerosing cholangitis (PSC) is a chronic liver disease associated with inflammation and biliary fibrosis that leads to cholangitis, cirrhosis, and impaired quality of life. Our objective was to develop and validate a PSC‐specific patient‐reported outcome (PRO) instrument.