Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial

Julie Thompson, Natasha Jones, Ali Al‐Khafaji, Shahid Malik, David Reich, Santiago Munoz, Ross MacNicholas, Tarek Hassanein, Lewis Teperman, Lance Stein, Andrés Duarte‐Rojo, Raza Malik, Talal Adhami, Sumeet Asrani, Nikunj Shah, Paul Gaglio, Anupama Duddempudi, Brian Borg, Rajiv Jalan, Robert Brown, Heather Patton, Rohit Satoskar, Simona Rossi, Amay Parikh, Ahmed ElSharkawy, Parvez Mantry, Linda Sher, David Wolf, Marquis Hart, Charles Landis, Alan Wigg, Shahid Habib, Geoffrey McCaughan, Steven Colquhoun, Alyssa Henry, Patricia Bedard, Lee Landeen, Michael Millis, Robert Ashley, William Frank

Hypoxia‐inducible factor‐1α/interleukin‐1β signaling enhances hepatoma epithelial–mesenchymal transition through macrophages in a hypoxic‐inflammatory microenvironment

Jingying Zhang, Qi Zhang, Yu Lou, Qihan Fu, Qi Chen, Tao Wei, Jiaqi Yang, Jinlong Tang, Jianxin Wang, Yiwen Chen, Xiaoyu Zhang, Jian Zhang, Xueli Bai, Tingbo Liang – 23 November 2017 – The development and progression of hepatocellular carcinoma (HCC) are dependent on its local microenvironment. Hypoxia and inflammation are two critical factors that shape the HCC microenvironment; however, the interplay between the two factors and the involvement of cancer cells under such conditions remain poorly understood.

Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer

Andrija Matak, Pooja Lahiri, Ethan Ford, Daniela Pabst, Karl Kashofer, Dimitris Stellas, Dimitris Thanos, Kurt Zatloukal – 23 November 2017 – Intratumor heterogeneity is increasingly recognized as a major factor impacting diagnosis and personalized treatment of cancer. We characterized stochastic phenotype switching as a mechanism contributing to intratumor heterogeneity and malignant potential of liver cancer.

Actin cytoskeleton remodeling drives epithelial‐mesenchymal transition for hepatoma invasion and metastasis in mice

Jei‐Ming Peng, Rabindranath Bera, Chih‐Yung Chiou, Ming‐Chin Yu, Tse‐Chin Chen, Chia‐Wei Chen, Tsung‐Rui Wang, Wan‐Ling Chiang, Shin‐Pei Chai, Yongkun Wei, Huamin Wang, Mien‐Chie Hung, Sen‐Yung Hsieh – 23 November 2017 – High invasiveness is a hallmark of human hepatocellular carcinoma (HCC). Large tumors predict invasion and metastasis. Epithelial‐mesenchymal transition (EMT) is crucial for cancer invasion and metastasis. However, the mechanisms whereby large tumors tend to undergo EMT remain unclear.

Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer

Andrija Matak, Pooja Lahiri, Ethan Ford, Daniela Pabst, Karl Kashofer, Dimitris Stellas, Dimitris Thanos, Kurt Zatloukal – 23 November 2017 – Intratumor heterogeneity is increasingly recognized as a major factor impacting diagnosis and personalized treatment of cancer. We characterized stochastic phenotype switching as a mechanism contributing to intratumor heterogeneity and malignant potential of liver cancer.

Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population

Fredrik Åberg, Jaana Helenius‐Hietala, Pauli Puukka, Martti Färkkilä, Antti Jula – 22 November 2017 – The metabolic syndrome and alcohol risk use are both associated with a high prevalence of hepatic steatosis, but only a minority develop liver failure or liver cancer. Few general population studies have analyzed metabolic predictors of such severe liver complications.

Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population

Fredrik Åberg, Jaana Helenius‐Hietala, Pauli Puukka, Martti Färkkilä, Antti Jula – 22 November 2017 – The metabolic syndrome and alcohol risk use are both associated with a high prevalence of hepatic steatosis, but only a minority develop liver failure or liver cancer. Few general population studies have analyzed metabolic predictors of such severe liver complications.

External validation of the ITA.LI.CA prognostic system for patients with hepatocellular carcinoma: A multicenter cohort study

Mauro Borzio, Elena Dionigi, Angelo Rossini, Massimo Marignani, Rodolfo Sacco, Ilario De Sio, Emanuela Bertolini, Giampiero Francica, Anna Giacomin, Giancarlo Parisi, Susanna Vicari, Anna Toldi, Andrea Salmi, Sergio Boccia, Mario Mitra, Fabio Fornari – 22 November 2017 – Several staging systems for hepatocellular carcinoma (HCC) have been developed. The Barcelona Clinic Liver Cancer staging system is considered the best in predicting survival, although limitations have emerged.

Subscribe to