Attitudes and barriers to the use of donation after cardiac death livers: Comparison of a United States transplant center survey to the United Network for Organ Sharing data
Marit Kalisvaart, Andrea Schlegel, Paolo Muiesan – 15 November 2017
β‐Catenin and interleukin‐1β–dependent chemokine (C‐X‐C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis
Eleanna Kaffe, Romina Fiorotto, Francesca Pellegrino, Valeria Mariotti, Mariangela Amenduni, Massimiliano Cadamuro, Luca Fabris, Mario Strazzabosco, Carlo Spirli – 15 November 2017 – Congenital hepatic fibrosis (CHF), a genetic disease caused by mutations in the polycystic kidney and hepatic disease 1 (PKHD1) gene, encoding for the protein fibrocystin/polyductin complex, is characterized by biliary dysgenesis, progressive portal fibrosis, and a protein kinase A–mediated activating phosphorylation of β‐catenin at Ser675.
MicroRevolution in understanding primary biliary cholangitis pathophysiology
Marta B. Afonso, Cecília M.P. Rodrigues – 15 November 2017
Long noncoding RNA H19 interacts with polypyrimidine tract‐binding protein 1 to reprogram hepatic lipid homeostasis
Chune Liu, Zhihong Yang, Jianguo Wu, Li Zhang, Sangmin Lee, Dong‐Ju Shin, Melanie Tran, Li Wang – 15 November 2017 – H19 is an imprinted long noncoding RNA abundantly expressed in embryonic liver and repressed after birth. We show that H19 serves as a lipid sensor by synergizing with the RNA‐binding polypyrimidine tract‐binding protein 1 (PTBP1) to modulate hepatic metabolic homeostasis. H19 RNA interacts with PTBP1 to facilitate its association with sterol regulatory element‐binding protein 1c mRNA and protein, leading to increased stability and nuclear transcriptional activity.
Perioperative von Willebrand factor dynamics are associated with liver regeneration and predict outcome after liver resection
Patrick Starlinger, David Pereyra, Stefanie Haegele, Paul Braeuer, Lukas Oehlberger, Florian Primavesi, Andreas Kohler, Florian Offensperger, Thomas Reiberger, Arnulf Ferlitsch, Barbara Messner, Guido Beldi, Stefan Staettner, Christine Brostjan, Thomas Gruenberger – 15 November 2017 – von Willebrand Factor (vWF) was found to mediate platelet influx during the early phase of liver regeneration in mice. Furthermore, increased vWF‐antigen (vWF‐Ag) levels were shown to be predictive for outcome of patients with chronic liver disease.
Is liver transplantation for intractable attacks of porphyria a viable treatment in a developing country?
Daniel A. Jaramillo‐Calle, Omar Castaño Quintero, Juan‐Ignacio Marín, Alicia M. Cock‐Rada, Oscar Santos Sánchez, Octavio Muñoz, Juan‐Carlos Restrepo – 15 November 2017
Pilot study of living donor liver transplantation for patients with hepatocellular carcinoma exceeding Milan Criteria (Barcelona Clinic Liver Cancer extended criteria)
Josep M. Llovet, Mihai Pavel, Jordi Rimola, Maria Alba Diaz, Jordi Colmenero, David Saavedra-Perez, Constantino Fondevila, Carmen Ayuso, Josep Fuster, Pere Ginès, Jordi Bruix, Juan Carlos Garcia-Valdecasas – 15 November 2017 – A subset of patients with hepatocellular carcinoma (HCC) beyond Milan criteria might obtain acceptable survival outcomes after liver transplantation. Living donor liver transplantation (LDLT) has emerged as a feasible alternative to overcome the paucity of donors.
Osteopontin deletion drives hematopoietic stem cell mobilization to the liver and increases hepatic iron contributing to alcoholic liver disease
Fernando Magdaleno, Xiaodong Ge, Holger Fey, Yongke Lu, Harriet Gaskell, Chuck C. Blajszczak, Costica Aloman, M. Isabel Fiel, Natalia Nieto – 12 November 2017 – The aim of this study was to investigate the role of osteopontin (OPN) in hematopoietic stem cell (HPSC) mobilization to the liver and its contribution to alcoholic liver disease (ALD). We analyzed young (14‐16 weeks) and old (>1.5 years) wild‐type (WT) littermates and global Opn knockout (Opn−/−) mice for HPSC mobilization to the liver. In addition, WT and Opn−/− mice were chronically fed the Lieber–DeCarli diet for 7 weeks.
Newly discovered hepatitis C virus minicores circulate in human blood
Francis J. Eng, Ahmed El‐Shamy, Erin H. Doyle, Arielle Klepper, A. Scott Muerhoff, Andrea D. Branch – 12 November 2017 – Hepatitis C virus (HCV) is one of the most prevalent causes of chronic blood‐borne infections worldwide. Despite developments of highly effective treatments, most infected individuals are unaware of their infection. Approximately 75% of infections are in low‐ and middle‐income countries; therefore, continuing research in HCV molecular virology and the development of vaccines and affordable diagnostics is required to reduce the global burden.
Interaction between the patatin‐like phospholipase domain‐containing protein 3 genotype and coffee drinking and the risk for acute alcoholic hepatitis
Suthat Liangpunsakul, James J. Beaudoin, Vijay H. Shah, Puneet Puri, Arun J. Sanyal, Patrick S. Kamath, Spencer G. Lourens, Qing Tang, Barry P. Katz, David W. Crabb, Naga P. Chalasani – 11 November 2017 – Only a subset of subjects with excessive alcohol consumption develops alcoholic liver disease (ALD). One of the major risk factors for ALD is the genetic variant of the patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) gene. Coffee is one of the most commonly consumed beverages, and coffee consumption has been associated with lower levels of serum alanine aminotransferase.