Nipun Verma, Shreya Singh, Gitesh Sawatkar, Virendra Singh – 11 November 2017 – Sofosbuvir is an imperative drug used in treatment regimens for hepatitis C virus (HCV). It is considered relatively safe with fewer adverse effects than other treatments. Here, we report a rare and potentially serious, dermatologic, adverse effect following the use of sofosbuvir. A 35‐year‐old man with genotype 3‐related HCV cirrhosis presented with decompensated ascites and jaundice following 7 weeks of therapy with peginterferon alpha‐2a and oral ribavirin.

Suthat Liangpunsakul, James J. Beaudoin, Vijay H. Shah, Puneet Puri, Arun J. Sanyal, Patrick S. Kamath, Spencer G. Lourens, Qing Tang, Barry P. Katz, David W. Crabb, Naga P. Chalasani – 11 November 2017 – Only a subset of subjects with excessive alcohol consumption develops alcoholic liver disease (ALD). One of the major risk factors for ALD is the genetic variant of the patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) gene. Coffee is one of the most commonly consumed beverages, and coffee consumption has been associated with lower levels of serum alanine aminotransferase.

Qiang Liu, Ahmed Nassar, Laura Buccini, Giuseppe Iuppa, Basem Soliman, Daniele Pezzati, Ahmed Hassan, Matthew Blum, William Baldwin, Ana Bennett, Kenneth Chavin, Toshihiro Okamoto, Teresa Diago Uso, John Fung, Kareem Abu‐Elmagd, Charles Miller, Cristiano Quintini – 10 November 2017 – Normothermic machine perfusion (NMP) is an emerging technology to preserve liver allografts more effectively than cold storage (CS). However, little is known about the effect of NMP on steatosis and the markers indicative of hepatic quality during NMP.

Benedikt Schaefer, Heinz Zoller, Stefan Schneeberger – 10 November 2017 – Organ shortage requires policies and guidelines to aid organ allocation along the principles of urgency or utility. Identifying patients with significant benefit and withholding liver transplantation (LT) from patients too sick for transplantation are ongoing challenges, in particular in patients with malignancies. An arbitrary threshold of >50% 5‐year overall survival (OS) is broadly considered a minimum standard for LT.

Nicolás Goldaracena, Andre Gorgen, Gonzalo Sapisochin – 10 November 2017

Allison Kwong, W. Ray Kim, Ajitha Mannalithara, Nae‐Yun Heo, Prowpanga Udompap, Donghee Kim – 10 November 2017 – Hepatitis C virus (HCV) infection has been the leading indication for liver transplantation (LT) in the United States. Since 2013, interferon‐free antiviral therapy has led to sustained virological response in many LT candidates. We compared the wait‐list mortality of HCV patients with that of patients with other chronic liver diseases. Data for primary LT candidates were obtained from the Organ Procurement and Transplantation Network database.

Seogsong Jeong, Meng Sha, Qiang Xia – 10 November 2017

Jennifer A. Woo Baidal, Erika R. Cheng, Sheryl L. Rifas‐Shiman, Emily Oken, Matthew W. Gillman, Elsie M. Taveras – 9 November 2017 – The extent to which vitamin E (alpha‐tocopherol) intake early in childhood is associated with alanine aminotransferase (ALT) level later in childhood is unknown. The objective of this research is to test the hypothesis that higher alpha‐tocopherol intake during early childhood is associated with lower odds of elevated ALT levels during mid‐childhood and to examine how body mass index (BMI) influences these relationships.

Jung Eun Park, Mikang Lee, Seong‐Chul Kim, Yanqiao Zhang, James P. Hardwick, Yoon Kwang Lee – 8 November 2017 – Peroxisome proliferator‐activated receptor gamma (PPARγ) is a master regulator for white adipocyte differentiation and lipid storage. The increased level of hepatic PPARγ2 isoform reprograms liver for lipid storage and causes abnormal fat accumulation in certain pathophysiologic conditions. The current study aimed to investigate a role of transcriptional repressor hairy and enhancer of split 6 (HES6) in the regulation of Pparg2 expression and hepatic steatosis induced by diet.

Anke Hermann, Dirk Oliver Wennmann, Sascha Gromnitza, Maria Edeling, Veerle Van Marck, Marius Sudol, Liliana Schaefer, Kerstin Duning, Thomas Weide, Hermann Pavenstädt, Joachim Kremerskothen – 8 November 2017 – The Hippo pathway regulates cell differentiation, proliferation, and apoptosis. Upon activation, it inhibits the import of the transcriptional coactivator yes‐associated protein (YAP) into the nucleus, thus suppressing transcription of pro‐proliferative genes.