Yanfeng Liu, Yonglong Zhang, Shenghao Wang, Qiong‐Zhu Dong, Zhongliang Shen, Wei Wang, Shuai Tao, Chenjian Gu, Jing Liu, Youhua Xie, Lun‐Xiu Qin – 23 June 2017 – Angiogenesis has been proven to play an important role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanism underlying HCC angiogenesis is not well understood. In this study, Prospero‐related homeobox 1 (PROX1) was identified as a novel proangiogenic factor in HCC cell lines and tissues. A strong positive correlation was found between the levels of PROX1 and microvessel density in HCC tissues.

Chiao‐Ling Tsai, Wei‐Lin Liu, Feng‐Ming Hsu, Po‐Sheng Yang, Ruoh‐Fang Yen, Kai‐Yuan Tzen, Ann‐Lii Cheng, Pei‐Jer Chen, Jason Chia‐Hsien Cheng – 23 June 2017 – Several strategies to improve the efficacy of radiation therapy against hepatocellular carcinoma (HCC) have been investigated. One approach is to develop radiosensitizing compounds.

Lian Yee Yip, Chiu Cheong Aw, Sze Han Lee, Yi Shuen Hong, Han Chen Ku, Winston Hecheng Xu, Jessalyn Mei Xuan Chan, Eleanor Jing Yi Cheong, Kern Rei Chng, Amanda Hui Qi Ng, Niranjan Nagarajan, Ratha Mahendran, Yuan Kun Lee, Edward R. Browne, Eric Chun Yong Chan – 23 June 2017 – The gut microbiota possesses diverse metabolic activities, but its contribution toward heterogeneous toxicological responses is poorly understood. In this study, we investigated the role of the liver–gut microbiota axis in underpinning the hepatotoxicity of tacrine.

Chao Zhang, Jing Huang, Wei An – 23 June 2017 – Ischemia/reperfusion injury, induced by abnormal mitochondrial fission–related apoptosis, is a major concern in liver transplantation settings. Our previous studies have demonstrated that hepatic stimulator substance (HSS) is an antiapoptotic effector and could protect liver from ischemia/reperfusion injury. However, the underlying mechanism remains unclear.

Paul A. Dawson – 23 June 2017

Elodie Henriet, Aya Abou Hammoud, Jean‐William Dupuy, Benjamin Dartigues, Zakaria Ezzoukry, Nathalie Dugot‐Senant, Thierry Leste‐Lasserre, Nestor Pallares‐Lupon, Macha Nikolski, Brigitte Le Bail, Jean‐Frédéric Blanc, Charles Balabaud, Paulette Bioulac‐Sage, Anne‐Aurélie Raymond, Frédéric Saltel – 23 June 2017 – Hepatocellular adenomas (HCAs) are rare benign tumors divided into three main subgroups defined by pathomolecular features, HNF1A (H‐HCA), mutated β‐catenin (b‐HCA), and inflammatory (IHCA).

Saumya Pandey – 23 June 2017

José Altamirano, Hugo López‐Pelayo, Javier Michelena, Patricia D. Jones, Lluisa Ortega, Pere Ginès, Juan Caballería, Antoni Gual, Ramón Bataller, Anna Lligoña – 23 June 2017 – Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease. Most studies have focused on short‐term prognosis, whereas factors associated with long‐term survival are largely unknown.

22 June 2017

Dae‐Soo Kim, Jea‐Woon Ryu, Mi‐Young Son, Jung‐Hwa Oh, Kyung‐Sook Chung, Sugi Lee, Jeong‐Ju Lee, Jun‐Ho Ahn, Ju‐Sik Min, Jiwon Ahn, Hyun Mi Kang, Janghwan Kim, Cho‐Rok Jung, Nam‐Soon Kim, Hyun‐Soo Cho – 22 June 2017 – Alternative cell sources, such as three‐dimensional organoids and induced pluripotent stem cell–derived cells, might provide a potentially effective approach for both drug development applications and clinical transplantation.