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Patatin‐like phospholipase domain containing 3 variants differentially impact metabolic traits in individuals at high risk for cardiovascular events

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Sabrina Rüschenbaum, Katharina Schwarzkopf, Mireen Friedrich‐Rust, Florian Seeger, Fabian Schoelzel, Yolanda Martinez, Stefan Zeuzem, Jörg Bojunga, Christian M. Lange – 6 June 2018 – Single nucleotide polymorphism (SNP) rs738409 C>G in the patatin‐like phospholipase domain containing 3 (PNPLA3) gene results in an amino acid exchange from isoleucin to methionine at position I148M of PNPLA3.

Treatment of the extrahepatic manifestations of chronic hepatitis C infection

Read more about Treatment of the extrahepatic manifestations of chronic hepatitis C infection

Karn Wijarnpreecha, Wisit Cheungpasitporn, Surakit Pungpapong, Kiran R. Nakkala – 5 June 2018

Imaging of abnormal liver function tests

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Saivenkat H. Vagvala, Stacy D. O'Connor – 5 June 2018

PRO (“The Window Is Open”): In patients with cirrhosis with prior variceal hemorrhage and ascites, the clinical benefits of nonselective beta‐blockers outweigh the risks and should be prescribed

Read more about PRO (“The Window Is Open”): In patients with cirrhosis with prior variceal hemorrhage and ascites, the clinical benefits of nonselective beta‐blockers outweigh the risks and should be prescribed

Danielle Tholey, Nitzan Roth, Thomas Schiano – 5 June 2018

Hepatic fibrosis: Avenues of investigation and clinical implications

Read more about Hepatic fibrosis: Avenues of investigation and clinical implications

Jessica E.S. Shay, James P. Hamilton – 5 June 2018

Risk factors, scoring systems, and interventions for alcohol relapse after liver transplantation for alcoholic liver disease

Read more about Risk factors, scoring systems, and interventions for alcohol relapse after liver transplantation for alcoholic liver disease

Jane Lim, Vinay Sundaram – 5 June 2018

CON (“The window is closed”): In patients with cirrhosis with ascites, the clinical risks of nonselective beta‐blocker outweigh the benefits and should NOT be prescribed

Read more about CON (“The window is closed”): In patients with cirrhosis with ascites, the clinical risks of nonselective beta‐blocker outweigh the benefits and should NOT be prescribed

Ariel W. Aday, Nicole E. Rich, Arjmand R. Mufti, Shannan R. Tujios – 5 June 2018

Treatment of the extrahepatic manifestations of chronic hepatitis C infection

Read more about Treatment of the extrahepatic manifestations of chronic hepatitis C infection

Karn Wijarnpreecha, Wisit Cheungpasitporn, Surakit Pungpapong, Kiran R. Nakkala – 5 June 2018

Issue Information

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1 June 2018

Coagulation Failure in Patients With Acute‐on‐Chronic Liver Failure and Decompensated Cirrhosis: Beyond the International Normalized Ratio

Read more about Coagulation Failure in Patients With Acute‐on‐Chronic Liver Failure and Decompensated Cirrhosis: Beyond the International Normalized Ratio

Annabel Blasi, Andrea Calvo, Verónica Prado, Enric Reverter, Juan Carlos Reverter, María Hernández‐Tejero, Fátima Aziz, Alex Amoros, Andres Cardenas, Javier Fernández – 23 May 2018 – Balanced hemostasis with hypocoagulable and hypercoagulable features may occur in acute‐on‐chronic liver failure (ACLF). The characteristics and prognostic impact of the coagulation profile in ACLF are unknown. Consecutive patients with ACLF (n = 36) and acute decompensation (AD; n = 24) were included. Blood samples for thromboelastometry (TE) were obtained at admission and 72 hours thereafter.

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