Critical care management of the patient with cirrhosis awaiting liver transplant in the intensive care unit

Jody C. Olson, Constantine J. Karvellas – 8 July 2017 – Patients with cirrhosis who are awaiting liver transplantation (LT) are at high risk for developing critical illnesses. Current liver allocation policies that dictate a “sickest first” approach coupled with a mismatch between need and availability of organs result in longer wait times, and thus, patients are becoming increasingly ill while awaiting organ transplantation.

Grazoprevir, ruzasvir, and uprifosbuvir for hepatitis C virus after NS5A treatment failure

David Wyles, Heiner Wedemeyer, Ziv Ben‐Ari, Edward J. Gane, Jesper Bach Hansen, Ira M. Jacobson, Alex L. Laursen, Annie Luetkemeyer, Ronald Nahass, Stephen Pianko, Stefan Zeuzem, Patricia Jumes, Hsueh‐Cheng Huang, Joan Butterton, Michael Robertson, Janice Wahl, Eliav Barr, Hee‐Koung Joeng, Elizabeth Martin, Lawrence Serfaty, for the C‐CREST Part C and C‐SURGE Investigators – 7 July 2017 – People with hepatitis C virus (HCV) infection who have failed treatment with an all‐oral regimen represent a challenging treatment population.

Determination of hepatocellular carcinoma grade by needle biopsy is unreliable for liver transplant candidate selection

Colin M. Court, Michael P. Harlander‐Locke, Daniela Markovic, Samuel W. French, Bita V. Naini, David S. Lu, Steven S. Raman, Fady M. Kaldas, Ali Zarrinpar, Douglas G. Farmer, Richard S. Finn, Saeed Sadeghi, James S. Tomlinson, Ronald W. Busuttil, Vatche G. Agopian – 7 July 2017 – The objective of this article is to evaluate the utility of preoperative needle biopsy (PNB) grading of hepatocellular carcinoma (HCC) as a biomarker for liver transplantation (LT) candidate selection.

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