Exercise and NAFLD: Is it worth the effort?
George G. Schweitzer, Samuel Klein – 7 July 2017
Grazoprevir, ruzasvir, and uprifosbuvir for hepatitis C virus after NS5A treatment failure
David Wyles, Heiner Wedemeyer, Ziv Ben‐Ari, Edward J. Gane, Jesper Bach Hansen, Ira M. Jacobson, Alex L. Laursen, Annie Luetkemeyer, Ronald Nahass, Stephen Pianko, Stefan Zeuzem, Patricia Jumes, Hsueh‐Cheng Huang, Joan Butterton, Michael Robertson, Janice Wahl, Eliav Barr, Hee‐Koung Joeng, Elizabeth Martin, Lawrence Serfaty, for the C‐CREST Part C and C‐SURGE Investigators – 7 July 2017 – People with hepatitis C virus (HCV) infection who have failed treatment with an all‐oral regimen represent a challenging treatment population.
A single‐cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation
Li Yang, Wei‐Hua Wang, Wei‐Lin Qiu, Zhen Guo, Erfei Bi, Cheng‐Ran Xu – 6 July 2017 – How bipotential hepatoblasts differentiate into hepatocytes and cholangiocytes remains unclear. Here, using single‐cell transcriptomic analysis of hepatoblasts, hepatocytes, and cholangiocytes sorted from embryonic day 10.5 (E10.5) to E17.5 mouse embryos, we found that hepatoblast‐to‐hepatocyte differentiation occurred gradually and followed a linear default pathway. As more cells became fully differentiated hepatocytes, the number of proliferating cells decreased.
Hospital volume and mortality after transjugular intrahepatic portosystemic shunt creation in the United States
Ammar Sarwar, Lujia Zhou, Victor Novack, Elliot B. Tapper, Michael Curry, Raza Malik, Muneeb Ahmed – 6 July 2017 – The link between higher procedure volume and better outcomes for surgical procedures is well established. We aimed to determine whether procedure volume affected inpatient mortality in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS). An epidemiological analysis of an all‐payer database recording hospitalizations during 2013 in the United States (Nationwide Readmissions Database) was performed.
Hospital volume and mortality after transjugular intrahepatic portosystemic shunt creation in the United States
Ammar Sarwar, Lujia Zhou, Victor Novack, Elliot B. Tapper, Michael Curry, Raza Malik, Muneeb Ahmed – 6 July 2017 – The link between higher procedure volume and better outcomes for surgical procedures is well established. We aimed to determine whether procedure volume affected inpatient mortality in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS). An epidemiological analysis of an all‐payer database recording hospitalizations during 2013 in the United States (Nationwide Readmissions Database) was performed.
Is the regulatory effect of PCAF and sirtuin 7 on phosphoglycerate kinase 1 acetylation a universal mechanism underlying hepatocellular carcinoma progression?
Changwei Dou, Xin Zheng, Qingguang Liu, Kangsheng Tu – 6 July 2017
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Angels Escorsell, Jaime Bosch – 6 July 2017
Alcoholic hepatitis: Continued drinking and the mourning after
Douglas A. Simonetto, Patrick S. Kamath, Vijay H. Shah – 3 July 2017
Role of ErbB/HER family of receptor tyrosine kinases in cholangiocyte biology
Anna Pellat, Javier Vaquero, Laura Fouassier – 3 July 2017 – The ErbB/HER family comprises four distinct tyrosine kinase receptors, EGFR/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4, which trigger intracellular signals at the origin of essential cellular functions, including differentiation, proliferation, survival, and migration. Epithelial cells, named cholangiocytes, that line intrahepatic and extrahepatic bile ducts, contribute substantially to biliary secretory functions and bile transport.
Role of ErbB/HER family of receptor tyrosine kinases in cholangiocyte biology
Anna Pellat, Javier Vaquero, Laura Fouassier – 3 July 2017 – The ErbB/HER family comprises four distinct tyrosine kinase receptors, EGFR/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4, which trigger intracellular signals at the origin of essential cellular functions, including differentiation, proliferation, survival, and migration. Epithelial cells, named cholangiocytes, that line intrahepatic and extrahepatic bile ducts, contribute substantially to biliary secretory functions and bile transport.