The liver–gut microbiota axis modulates hepatotoxicity of tacrine in the rat

Lian Yee Yip, Chiu Cheong Aw, Sze Han Lee, Yi Shuen Hong, Han Chen Ku, Winston Hecheng Xu, Jessalyn Mei Xuan Chan, Eleanor Jing Yi Cheong, Kern Rei Chng, Amanda Hui Qi Ng, Niranjan Nagarajan, Ratha Mahendran, Yuan Kun Lee, Edward R. Browne, Eric Chun Yong Chan – 23 June 2017 – The gut microbiota possesses diverse metabolic activities, but its contribution toward heterogeneous toxicological responses is poorly understood. In this study, we investigated the role of the liver–gut microbiota axis in underpinning the hepatotoxicity of tacrine.

Targeting histone deacetylase 4/ubiquitin‐conjugating enzyme 9 impairs DNA repair for radiosensitization of hepatocellular carcinoma cells in mice

Chiao‐Ling Tsai, Wei‐Lin Liu, Feng‐Ming Hsu, Po‐Sheng Yang, Ruoh‐Fang Yen, Kai‐Yuan Tzen, Ann‐Lii Cheng, Pei‐Jer Chen, Jason Chia‐Hsien Cheng – 23 June 2017 – Several strategies to improve the efficacy of radiation therapy against hepatocellular carcinoma (HCC) have been investigated. One approach is to develop radiosensitizing compounds.

Prospero‐related homeobox 1 drives angiogenesis of hepatocellular carcinoma through selectively activating interleukin‐8 expression

Yanfeng Liu, Yonglong Zhang, Shenghao Wang, Qiong‐Zhu Dong, Zhongliang Shen, Wei Wang, Shuai Tao, Chenjian Gu, Jing Liu, Youhua Xie, Lun‐Xiu Qin – 23 June 2017 – Angiogenesis has been proven to play an important role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanism underlying HCC angiogenesis is not well understood. In this study, Prospero‐related homeobox 1 (PROX1) was identified as a novel proangiogenic factor in HCC cell lines and tissues. A strong positive correlation was found between the levels of PROX1 and microvessel density in HCC tissues.

The emergence of NS5B resistance associated substitution S282T after sofosbuvir‐based treatment

Edward J. Gane, Sophie Metivier, Ronald Nahass, Michael Ryan, Catherine A. Stedman, Evguenia S. Svarovskaia, Hongmei Mo, Brian Doehle, Hadas Dvory‐Sobol, Charlotte Hedskog, Ming Lin, Diana M. Brainard, Jenny C. Yang, John G. McHutchison, Mark Sulkowski, Ziad Younes, Eric Lawitz – 22 June 2017 – S282T in NS5B is the primary amino acid substitution associated with resistance to sofosbuvir (SOF) but has rarely been detected in patients treated with a SOF‐based regimen.

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