Masthead
22 June 2017
A liver‐specific gene expression panel predicts the differentiation status of in vitro hepatocyte models
Dae‐Soo Kim, Jea‐Woon Ryu, Mi‐Young Son, Jung‐Hwa Oh, Kyung‐Sook Chung, Sugi Lee, Jeong‐Ju Lee, Jun‐Ho Ahn, Ju‐Sik Min, Jiwon Ahn, Hyun Mi Kang, Janghwan Kim, Cho‐Rok Jung, Nam‐Soon Kim, Hyun‐Soo Cho – 22 June 2017 – Alternative cell sources, such as three‐dimensional organoids and induced pluripotent stem cell–derived cells, might provide a potentially effective approach for both drug development applications and clinical transplantation.
Notices
22 June 2017
The emergence of NS5B resistance associated substitution S282T after sofosbuvir‐based treatment
Edward J. Gane, Sophie Metivier, Ronald Nahass, Michael Ryan, Catherine A. Stedman, Evguenia S. Svarovskaia, Hongmei Mo, Brian Doehle, Hadas Dvory‐Sobol, Charlotte Hedskog, Ming Lin, Diana M. Brainard, Jenny C. Yang, John G. McHutchison, Mark Sulkowski, Ziad Younes, Eric Lawitz – 22 June 2017 – S282T in NS5B is the primary amino acid substitution associated with resistance to sofosbuvir (SOF) but has rarely been detected in patients treated with a SOF‐based regimen.
Table of contents
22 June 2017
Long‐term survival after surveillance and treatment in patients with chronic viral hepatitis and hepatocellular carcinoma
Myron J. Tong, Alexander A. Rosinski, Claiborne T. Huynh, Steven S. Raman, David S.K. Lu – 21 June 2017 – Hepatocellular carcinoma (HCC) is the main cause of mortality in patients with chronic viral hepatitis (CVH). We determined the impact of surveillance and treatments on long‐term outcomes in patients with CVH who developed HCC. Between 1984 and 2014, 333 patients with HCC and with hepatitis B or hepatitis C virus infection were evaluated.