Palliative care access for hospitalized patients with end‐stage liver disease across the United States

Barret Rush, Keith R. Walley, Leo A. Celi, Neil Rajoriya, Mayur Brahmania – 29 June 2017 – Patients with end‐stage liver disease (ESLD) often have a high symptom burden. Historically, palliative care (PC) services have been underused in this population. We investigated the use of PC services in patients with ESLD hospitalized across the United States. We used the Nationwide Inpatient Sample to conduct a retrospective nationwide cohort analysis. All patients >18 years of age admitted with ESLD, defined as those with at least two liver decompensation events, were included in the analysis.

Idiosyncratic drug‐induced liver injury: A short review

Yo‐ichi Yamashita, Katsunori Imai, Kosuke Mima, Shigeki Nakagawa, Daisuke Hashimoto, Akira Chikamoto, Hideo Baba – 28 June 2017 – Idiosyncratic drug‐induced liver injury (iDILI) is a rare adverse drug reaction that occasionally leads to acute liver failure or even death. An aging population that uses more drugs, a constant influx of newly developed drugs, and a growing risk from herbal and dietary supplements of uncertain quality can lead to an increase in iDILI.

Pericentral hepatocytes produce insulin‐like growth factor‐2 to promote liver regeneration during selected injuries in mice

Junlai Liu, Xiao Hu, Jie Chen, Xinqi Li, Lu Wang, Binbin Wang, Wenbo Peng, Cuiwei Yang, Zhijie Li, Yan Chen, Yue J. Wang, Chuanjiang Li, Xiajun Li, Fang Yan, Yunfang Wang, Changzhen Shang, Xin Wang, Tao Chen, Pengyu Huang – 27 June 2017 – Liver regeneration (LR) happens after various types of injuries. Unlike the well‐studied LR caused by partial hepatectomy (PHx), there is accumulating evidence suggesting that LR during other injuries may result from unknown mechanisms.

Pregnancy outcome in women undergoing liver biopsy during pregnancy: A nationwide population‐based cohort study

Jonas F. Ludvigsson, Hanns‐Ulrich Marschall, Hannes Hagström, Jonas Höijer, Olof Stephansson – 27 June 2017 – Liver biopsy is an important procedure in the investigation of liver disease. We examined pregnancy outcomes in women who underwent liver biopsy during pregnancy. In a nationwide population‐based cohort study we linked data from the Swedish Medical Birth Registry (for births between 1992 and 2011) with those from the Swedish Patient Registry. We identified 23 pregnancies exposed to liver biopsy.

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