Is the regulatory effect of PCAF and sirtuin 7 on phosphoglycerate kinase 1 acetylation a universal mechanism underlying hepatocellular carcinoma progression?
Changwei Dou, Xin Zheng, Qingguang Liu, Kangsheng Tu – 6 July 2017
Hospital volume and mortality after transjugular intrahepatic portosystemic shunt creation in the United States
Ammar Sarwar, Lujia Zhou, Victor Novack, Elliot B. Tapper, Michael Curry, Raza Malik, Muneeb Ahmed – 6 July 2017 – The link between higher procedure volume and better outcomes for surgical procedures is well established. We aimed to determine whether procedure volume affected inpatient mortality in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS). An epidemiological analysis of an all‐payer database recording hospitalizations during 2013 in the United States (Nationwide Readmissions Database) was performed.
Hospital volume and mortality after transjugular intrahepatic portosystemic shunt creation in the United States
Ammar Sarwar, Lujia Zhou, Victor Novack, Elliot B. Tapper, Michael Curry, Raza Malik, Muneeb Ahmed – 6 July 2017 – The link between higher procedure volume and better outcomes for surgical procedures is well established. We aimed to determine whether procedure volume affected inpatient mortality in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS). An epidemiological analysis of an all‐payer database recording hospitalizations during 2013 in the United States (Nationwide Readmissions Database) was performed.
A single‐cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation
Li Yang, Wei‐Hua Wang, Wei‐Lin Qiu, Zhen Guo, Erfei Bi, Cheng‐Ran Xu – 6 July 2017 – How bipotential hepatoblasts differentiate into hepatocytes and cholangiocytes remains unclear. Here, using single‐cell transcriptomic analysis of hepatoblasts, hepatocytes, and cholangiocytes sorted from embryonic day 10.5 (E10.5) to E17.5 mouse embryos, we found that hepatoblast‐to‐hepatocyte differentiation occurred gradually and followed a linear default pathway. As more cells became fully differentiated hepatocytes, the number of proliferating cells decreased.
Role of ErbB/HER family of receptor tyrosine kinases in cholangiocyte biology
Anna Pellat, Javier Vaquero, Laura Fouassier – 3 July 2017 – The ErbB/HER family comprises four distinct tyrosine kinase receptors, EGFR/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4, which trigger intracellular signals at the origin of essential cellular functions, including differentiation, proliferation, survival, and migration. Epithelial cells, named cholangiocytes, that line intrahepatic and extrahepatic bile ducts, contribute substantially to biliary secretory functions and bile transport.
Role of ErbB/HER family of receptor tyrosine kinases in cholangiocyte biology
Anna Pellat, Javier Vaquero, Laura Fouassier – 3 July 2017 – The ErbB/HER family comprises four distinct tyrosine kinase receptors, EGFR/ErbB1/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4, which trigger intracellular signals at the origin of essential cellular functions, including differentiation, proliferation, survival, and migration. Epithelial cells, named cholangiocytes, that line intrahepatic and extrahepatic bile ducts, contribute substantially to biliary secretory functions and bile transport.
Alcoholic hepatitis: Continued drinking and the mourning after
Douglas A. Simonetto, Patrick S. Kamath, Vijay H. Shah – 3 July 2017
Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages
Xiaoming Cheng, Yuchen Xia, Elisavet Serti, Peter Daniel Block, Michelle Chung, Kazuaki Chayama, Barbara Rehermann, T. Jake Liang – 30 June 2017 – Hepatitis B virus (HBV) infects hepatocytes specifically and causes immune‐mediated liver damage. How HBV interacts with the innate immunity at the early phase of infection, either with hepatocytes or other cells in the liver, remains controversial. To address this question, we utilized various human cell‐culture models and humanized Alb‐uPA/SCID mice.
Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents
Oyekoya T. Ayonrinde, Leon A. Adams, Trevor A. Mori, Lawrence J. Beilin, Nicholas Klerk, Craig E. Pennell, Scott White, John K Olynyk – 30 June 2017 – Nonalcoholic fatty liver disease (NAFLD) is a complex chronic liver disorder. Examination of parental pregnancy‐related characteristics may provide insights into the origins of risk of NAFLD in offspring. We examined relationships between parental pregnancy‐related characteristics and NAFLD in 1,170 adolescent offspring aged 17 years participating in the Western Australian Pregnancy (Raine) Cohort Study.
Hepatitis C virus–induced tumor‐initiating cancer stem–like cells activate stromal fibroblasts in a xenograft tumor model
Reina Sasaki, Pradip Devhare, Ratna B. Ray, Ranjit Ray – 30 June 2017 – Hepatitis C virus (HCV) often causes persistent infection and is an increasingly important factor in the etiology of fibrosis/cirrhosis and hepatocellular carcinoma, although the mechanisms for the disease processes remain unclear. We have shown previously that HCV infection generates an epithelial–mesenchymal transition state and tumor‐initiating cancer stem–like cells in human hepatocytes.