Oncostatin M causes liver fibrosis by regulating cooperation between hepatic stellate cells and macrophages in mice
Michitaka Matsuda, Shinya Tsurusaki, Naoko Miyata, Eiko Saijou, Hitoshi Okochi, Atsushi Miyajima, Minoru Tanaka – 5 August 2017 – Fibrosis is an important wound‐healing process in injured tissues, but excessive fibrosis is often observed in patients with chronic inflammation. Although oncostatin M (OSM) has been reported to play crucial roles for recovery from acute liver injury by inducing tissue inhibitor of metalloproteinase 1 (Timp1) expression, the role of OSM in chronic liver injury (CLI) is yet to be elucidated.