Outcome of liver transplantation in patients with prior bariatric surgery

Mohamed Safwan, Kelly M. Collins, Marwan S. Abouljoud, Reena Salgia – 28 July 2017 – Nonalcoholic fatty liver disease is becoming the leading cause of disease resulting in liver transplantation (LT). As a result of this trend, more LT candidates are presenting with prior history of bariatric surgery (BS). Over the last decade, 960 patients underwent LT at our institution; 11 (1.1%) had prior BS. The most common type of BS was Roux‐en‐Y gastric bypass (n = 9) with 1 sleeve gastrectomy and 1 jejunoileal bypass.

Hepatocyte‐derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection

Dustin A. Cobb, Ok‐Kyung Kim, Lucy Golden‐Mason, Hugo R. Rosen, Young S. Hahn – 27 July 2017 – Hepatitis C virus (HCV) is a global health concern that can cause severe liver disease, such as cirrhosis and hepatocellular carcinoma. Control of HCV requires vigorous T‐cell responses, yet CD4+ T cells in chronic HCV patients are dysfunctional. T follicular regulatory (Tfr) cells are a subset of regulatory T cells that suppress T follicular helper (Tfh) cells and the generation of high affinity antibody‐producing B cells.

Impact of Sustained Virologic Response with Direct‐Acting Antiviral Treatment on Mortality in Patients with Advanced Liver Disease

Lisa I. Backus, Pamela S. Belperio, Troy A. Shahoumian, Larry A. Mole – 27 July 2017 – The impact of sustained virologic response (SVR) on mortality after direct‐acting antiviral treatment is not well documented. This study evaluated the impact of direct‐acting antiviral–induced SVR on all‐cause mortality and on incident hepatocellular carcinoma (HCC) in 15,059 hepatitis C virus–infected patients with advanced liver disease defined by a FIB‐4 >3.25. Overall, 1,067 patients did not achieve SVR (no SVR) and 13,992 patients achieved SVR.

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