Survival following hospitalization with hepatocellular carcinoma among people notified with hepatitis B or C virus in Australia (2000‐2014)

Reem Waziry, Jason Grebely, Janaki Amin, Maryam Alavi, Behzad Hajarizadeh, Jacob George, Gail V. Matthews, Matthew Law, Gregory J. Dore – 16 August 2017 – We assessed trends in HCC survival in patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection in New South Wales, Australia. Data on HBV (n = 54,399) and HCV (n = 96,908) notifications (1993‐2012) were linked to a hospitalization database (July 2000‐June 2014), the New South Wales Cancer Registry, and the New South Wales Death Registry.

Use of Mac‐2 binding protein as a biomarker for nonalcoholic fatty liver disease diagnosis

Yoshihiro Kamada, Masafumi Ono, Hideyuki Hyogo, Hideki Fujii, Yoshio Sumida, Makoto Yamada, Kojiroh Mori, Saiyu Tanaka, Tomohiro Maekawa, Yusuke Ebisutani, Akiko Yamamoto, Shinji Takamatsu, Masashi Yoneda, Norifumi Kawada, Kazuaki Chayama, Toshiji Saibara, Tetsuo Takehara, Eiji Miyoshi, Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG‐NAFLD) – 16 August 2017 – In contrast to patients with viral hepatitis, patients with nonalcoholic fatty liver disease (NAFLD) can progress to hepatocellular carcinoma during the initial stages of liver fibrosis.

Liver transplantation in adult cystic fibrosis: Clinical, imaging, and pathological evidence of obliterative portal venopathy

Sophie Hillaire, Dominique Cazals‐Hatem, Onorina Bruno, Sandra de Miranda, Dominique Grenet, Nicolas Poté, Olivier Soubrane, Serge Erlinger, Florence Lacaille, Francois Mellot, Valerie Vilgrain, Valerie Paradis – 16 August 2017

Curative salvage liver transplantation in patients with cirrhosis and hepatocellular carcinoma: An intention‐to‐treat analysis

Robbert J. de Haas, Chetana Lim, Prashant Bhangui, Chady Salloum, Philippe Compagnon, Cyrille Feray, Julien Calderaro, Alain Luciani, Daniel Azoulay – 14 August 2017 – The salvage liver transplantation (SLT) strategy was conceived for initially resectable and transplantable (R&T) hepatocellular carcinoma (HCC) patients, to try to obviate upfront liver transplantation, with the “safety net” of SLT in case of postresection recurrence. The SLT strategy is successful or curative when patients are recurrence free following primary resection alone, or after SLT for recurrence.

Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Anja Moncsek, Mohammed S. Al‐Suraih, Christy E. Trussoni, Steven P. O'Hara, Patrick L. Splinter, Camille Zuber, Eleonora Patsenker, Piero V. Valli, Christian D. Fingas, Achim Weber, Yi Zhu, Tamar Tchkonia, James L. Kirkland, Gregory J. Gores, Beat Müllhaupt, Nicholas F. LaRusso, Joachim C. Mertens – 12 August 2017 – Cholangiocyte senescence has been linked to primary sclerosing cholangitis (PSC). Persistent secretion of growth factors by senescent cholangiocytes leads to the activation of stromal fibroblasts (ASFs), which are drivers of fibrosis.

Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

Melania Gaggini, Fabrizia Carli, Chiara Rosso, Emma Buzzigoli, Milena Marietti, Veronica Della Latta, Demetrio Ciociaro, Maria Lorena Abate, Roberto Gambino, Maurizio Cassader, Elisabetta Bugianesi, Amalia Gastaldelli – 12 August 2017 – Plasma concentrations of amino acids (AAs), in particular, branched chain AAs (BCAAs), are often found increased in nonalcoholic fatty liver disease (NAFLD); however, if this is due to increased muscular protein catabolism, obesity, and/or increased insulin resistance (IR) or impaired tissue metabolism is unknown.

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

Chris Estes, Homie Razavi, Rohit Loomba, Zobair Younossi, Arun J. Sanyal – 12 August 2017 – Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are highly prevalent in the United States, where they are a growing cause of cirrhosis and hepatocellular carcinoma (HCC) and increasingly an indicator for liver transplantation. A Markov model was used to forecast NAFLD disease progression. Incidence of NAFLD was based on historical and projected changes in adult prevalence of obesity and type 2 diabetes mellitus (DM).

Subscribe to