Role of two‐dimensional shear wave elastography in the assessment of chronic liver diseases
Siddharth Singh, Rohit Loomba – 4 August 2017
The contribution of health risk behaviors to excess mortality in American adults with chronic hepatitis C: A population cohort‐study
Hamish Innes, Andrew McAuley, Maryam Alavi, Heather Valerio, David Goldberg, Sharon J. Hutchinson – 4 August 2017 – In resource‐rich countries, chronic hepatitis C (CHC) infection is associated with a sizeable excess mortality risk. The extent to which this is due to (1) the biological sequelae of CHC infection versus (2) a high concomitant burden of health risk behaviors (HRBs) is unclear. We used data from the 1999‐2010 U.S. National Health and Nutritional Examination Surveys (NHANES), which include detailed information on HRBs and CHC infection status.
Perinatal programming of adolescent nonalcoholic fatty liver disease: A case for gender inequality?
Monika Sarkar, Gyorgy Baffy – 3 August 2017
HCV and nonhepatic malignancy: Is pre‐emptive direct‐acting antiviral therapy indicated prior to treatment?
Michael Kriss, Matthew Burchill – 2 August 2017
Issue Information
2 August 2017
Impaired Rab7 and dynamin2 block fat turnover by autophagy in alcoholic fatty livers
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Yuan Li, Wen‐Xing Ding – 2 August 2017
Gastric perforation by stiff guidewire in Danis stent assembly
Ajinkya Sonambekar, Devendra Desai – 2 August 2017
LncRNA AK054921 and AK128652 are potential serum biomarkers and predictors of patient survival with alcoholic cirrhosis
Zhihong Yang, Ruth A Ross, Shi Zhao, Wanzhu Tu, Suthat Liangpunsakul, Li Wang – 2 August 2017 – Alcoholic liver disease (ALD) is one of the leading causes of chronic liver disease. Recent studies have demonstrated the roles of long noncoding RNAs (lncRNAs) in the pathogenesis of several disease processes. However, the roles of lncRNAs in patients with ALD remain unexplored.
Clinical endpoints and adaptive clinical trials in precirrhotic nonalcoholic steatohepatitis: Facilitating development approaches for an emerging epidemic
Claudia Filozof, Shein‐Chung Chow, Lara Dimick‐Santos, Yeh‐Fong Chen, Richard N. Williams, Barry J. Goldstein, Arun Sanyal – 1 August 2017 – Due to the increasing prevalence of nonalcoholic steatohepatitis (NASH) and its associated health burden, there is a high need to develop therapeutic strategies for patients with this disease. Unfortunately, its long and asymptomatic natural history, the uncertainties about disease progression, the fact that most patients are undiagnosed, and the requirement for sequential liver biopsies create substantial challenges for clinical development.
Remodeling the model for end‐stage liver disease for predicting mortality risk in critically ill patients with cirrhosis and acute kidney injury
Xiao‐Dong Zhou, Qin‐Fen Chen, Dan‐Qin Sun, Chen‐Fei Zheng, Dong‐Jie Liang, Jian Zhou, Song‐Jie Wang, Wen‐Yue Liu, Sven Poucke, Xiao‐Dong Wang, Ke‐Qing Shi, Wei‐Jian Huang, Ming‐Hua Zheng – 1 August 2017 – Serum creatinine measurement demonstrates a poor specificity and sensitivity for the early diagnosis of acute kidney injury (AKI) in patients with cirrhosis. The existing model for end‐stage liver disease (MELD) score reveals multiple pitfalls in critically ill patients with cirrhosis and acute kidney injury (CAKI).