Ethanol‐induced steatosis involves impairment of lipophagy, associated with reduced Dynamin2 activity

Karuna Rasineni, Terrence M. Donohue, Paul G. Thomes, Li Yang, Dean J. Tuma, Mark A. McNiven, Carol A. Casey – 10 July 2017 – Lipid droplets (LDs), the organelles central to alcoholic steatosis, are broken down by lipophagy, a specialized form of autophagy. Here, we hypothesize that ethanol administration retards lipophagy by down‐regulating dynamin 2 (Dyn2), a protein that facilitates lysosome re‐formation, contributing to hepatocellular steatosis. Primary hepatocytes were isolated from male Wistar rats fed Lieber–DeCarli control or ethanol (EtOH) liquid diets for 6‐8 weeks.

Critical care management of the patient with cirrhosis awaiting liver transplant in the intensive care unit

Jody C. Olson, Constantine J. Karvellas – 8 July 2017 – Patients with cirrhosis who are awaiting liver transplantation (LT) are at high risk for developing critical illnesses. Current liver allocation policies that dictate a “sickest first” approach coupled with a mismatch between need and availability of organs result in longer wait times, and thus, patients are becoming increasingly ill while awaiting organ transplantation.

Determination of hepatocellular carcinoma grade by needle biopsy is unreliable for liver transplant candidate selection

Colin M. Court, Michael P. Harlander‐Locke, Daniela Markovic, Samuel W. French, Bita V. Naini, David S. Lu, Steven S. Raman, Fady M. Kaldas, Ali Zarrinpar, Douglas G. Farmer, Richard S. Finn, Saeed Sadeghi, James S. Tomlinson, Ronald W. Busuttil, Vatche G. Agopian – 7 July 2017 – The objective of this article is to evaluate the utility of preoperative needle biopsy (PNB) grading of hepatocellular carcinoma (HCC) as a biomarker for liver transplantation (LT) candidate selection.

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