Influence of outflow‐obstructed liver volume and venous communication development: A three‐dimensional volume study in living donors

Yoshikuni Kawaguchi, Kiyoshi Hasegawa, Naoki Okura, Harufumi Maki, Nobuhisa Akamatsu, Junichi Kaneko, Junichi Arita, Yoshihiro Sakamoto, Kuni Ohtomo, Norihiro Kokudo – 17 August 2017 – Living donor liver transplantation using the left liver graft with the middle hepatic vein (MHV) is a well‐established procedure. Following such procedures, outflow obstruction occurs in remnant livers. However, the effects of the outflow‐obstructed liver volume (LVOut‐Ob), with or without venous communication development, remain unclear.

Increased myocardial contractility identifies patients with decompensated cirrhosis requiring liver transplantation

Christian Jansen, Alexander Cox, Robert Schueler, Matthias Schneider, Jennifer Lehmann, Michael Praktiknjo, Alessandra Pohlmann, Johannes Chang, Steffen Manekeller, Georg Nickenig, Gabriela Berlakovich, Christian P. Strassburg, Christoph Hammerstingl, Katharina Staufer, Jonel Trebicka – 17 August 2017 – Late allocation of organs for transplant impairs post–liver transplantation (LT) survival. Cardiac dysfunction, especially diastolic and autonomic dysfunction, is frequent and plays an important role in the prognosis of patients with cirrhosis.

A randomized, placebo‐controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

Scott L. Friedman, Vlad Ratziu, Stephen A. Harrison, Manal F. Abdelmalek, Guruprasad P. Aithal, Juan Caballeria, Sven Francque, Geoffrey Farrell, Kris V. Kowdley, Antonio Craxi, Krzysztof Simon, Laurent Fischer, Liza Melchor‐Khan, Jeffrey Vest, Brian L.

Projected increase in obesity and non‐alcoholic‐steatohepatitis–related liver transplantation waitlist additions in the United States

Neehar D. Parikh, Wesley J. Marrero, Jingyuan Wang, Justin Steuer, Elliot B. Tapper, Monica Konerman, Amit G. Singal, David W. Hutton, Eunshin Byon, Mariel S. Lavieri – 17 August 2017 – Nonalcoholic steatohepatitis (NASH) cirrhosis is the fastest growing indication for liver transplantation (LT) in the United States. We aimed to determine the temporal trend behind the rise in obesity and NASH‐related additions to the LT waitlist in the United States and make projections for future NASH burden on the LT waitlist.

MicroRNA‐337‐3p controls hepatobiliary gene expression and transcriptional dynamics during hepatic cell differentiation

Céline Demarez, Claude Gérard, Sabine Cordi, Alexis Poncy, Younes Achouri, Nicolas Dauguet, David A. Rosa, Patrick T. Gunning, Isabelle Manfroid, Frédéric P. Lemaigre – 17 August 2017 – Transcriptional networks control the differentiation of the hepatocyte and cholangiocyte lineages from embryonic liver progenitor cells and their subsequent maturation to the adult phenotype. However, how relative levels of hepatocyte and cholangiocyte gene expression are determined during differentiation remains poorly understood. Here, we identify microRNA (miR)‐337‐3p as a regulator of liver development.

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