Imaging for the diagnosis of hepatocellular carcinoma: A systematic review and meta‐analysis

Lewis R. Roberts, Claude B. Sirlin, Feras Zaiem, Jehad Almasri, Larry J. Prokop, Julie K. Heimbach, M. Hassan Murad, Khaled Mohammed – 31 August 2017 – Multiphasic computed tomography (CT) and magnetic resonance imaging (MRI) are both used for noninvasive diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis. To determine if there is a relative diagnostic benefit of one over the other, we synthesized evidence regarding the relative performance of CT, extracellular contrast–enhanced MRI, and gadoxetate‐enhanced MRI for diagnosis of HCC in patients with cirrhosis.

Performance characteristics of vibration‐controlled transient elastography for evaluation of nonalcoholic fatty liver disease

Raj Vuppalanchi, Mohammad S. Siddiqui, Mark L. Van Natta, Erin Hallinan, Danielle Brandman, Kris Kowdley, Brent A. Neuschwander‐Tetri, Rohit Loomba, Srinivas Dasarathy, Manal Abdelmalek, Edward Doo, James A. Tonascia, David E. Kleiner, Arun J. Sanyal, Naga Chalasani, for the NASH Clinical Research Network – 31 August 2017 – Vibration‐controlled transient elastography estimates liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), which are noninvasive assessments of hepatic fibrosis and steatosis, respectively.

Pregnancy in Wilson's disease: Management and outcome

Jan Pfeiffenberger, Sandra Beinhardt, Daniel N. Gotthardt, Nicola Haag, Clarissa Freissmuth, Ulrike Reuner, Annika Gauss, Wolfgang Stremmel, Michael L. Schilsky, Peter Ferenci, Karl Heinz Weiss – 31 August 2017 – Wilson's disease (WD) is a rare inherited disorder of copper metabolism causing toxic hepatic and neural copper accumulation. Clinical symptoms vary widely, from asymptomatic disease to acute liver failure or chronic liver disease with or without neuropsychiatric symptoms.

Therapies for patients with hepatocellular carcinoma awaiting liver transplantation: A systematic review and meta‐analysis

Laura Kulik, Julie K. Heimbach, Feras Zaiem, Jehad Almasri, Larry J Prokop, Zhen Wang, M. Hassan Murad, Khaled Mohammed – 31 August 2017 – Patients with hepatocellular carcinoma (HCC) who are listed for liver transplantation (LT) are often treated while on the waiting list with locoregional therapy (LRT), which is aimed at either preventing progression of HCC or reducing the measurable disease burden of HCC in order to receive increased allocation priority. We aimed to synthesize evidence regarding the effectiveness of LRT in the management of patients with HCC who were on the LT waitlist.

Projections of primary liver cancer to 2030 in 30 countries worldwide

Patricia C. Valery, Mathieu Laversanne, Paul J. Clark, Jessica L. Petrick, Katherine A. McGlynn, Freddie Bray – 31 August 2017 – Primary liver cancer (PLC) is the sixth most common cancer worldwide and the second most common cause of cancer death. Future predictions can inform health planners and raise awareness of the need for cancer control action. We predicted the future burden of PLC in 30 countries around 2030. Incident cases of PLC (International Classification of Diseases, Tenth Revision, C22) were obtained from 30 countries for 1993‐2007.

Therapies for patients with hepatocellular carcinoma awaiting liver transplantation: A systematic review and meta‐analysis

Laura Kulik, Julie K. Heimbach, Feras Zaiem, Jehad Almasri, Larry J Prokop, Zhen Wang, M. Hassan Murad, Khaled Mohammed – 31 August 2017 – Patients with hepatocellular carcinoma (HCC) who are listed for liver transplantation (LT) are often treated while on the waiting list with locoregional therapy (LRT), which is aimed at either preventing progression of HCC or reducing the measurable disease burden of HCC in order to receive increased allocation priority. We aimed to synthesize evidence regarding the effectiveness of LRT in the management of patients with HCC who were on the LT waitlist.

Continuous renal replacement therapy is associated with reduced serum ammonia levels and mortality in acute liver failure

Filipe S. Cardoso, Michelle Gottfried, Shannan Tujios, Jody C. Olson, Constantine J. Karvellas, For the US Acute Liver Failure Study Group – 31 August 2017 – Hyperammonemia has been associated with intracranial hypertension and mortality in patients with acute liver failure (ALF). We evaluated the effect of renal replacement therapy (RRT) on serum ammonia level and outcomes in ALF. This was a multicenter cohort study of consecutive ALF patients from the United States ALF Study Group registry between January 1998 and December 2016.

Significance of definitions of relapse after discontinuation of oral antivirals in HBeAg‐negative chronic hepatitis B

George V. Papatheodoridis, Spilios Manolakopoulos, Tung‐Hung Su, Spyros Siakavellas, Chun‐Jen Liu, Anastasia Kourikou, Hung‐Chih Yang, Jia‐Horng Kao – 31 August 2017 – Relapses are observed in most hepatitis B e antigen (HBeAg)‐negative chronic hepatitis B patients who discontinue treatment with nucleos(t)ide analogues (NAs); however, the rates of relapse vary widely among studies, and whether all patients with relapse need retreatment is unclear.

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