Vinay Sundaram, Einar S. Björnsson – 11 September 2017 – Cholestatic drug‐induced liver injury (DILI) can be a diagnostic challenge due to a large differential diagnosis, variability in clinical presentation, and lack of serologic biomarkers associated with this condition. The clinical presentation of drug‐induced cholestasis includes bland cholestasis, cholestatic hepatitis, secondary sclerosing cholangitis, and vanishing bile duct syndrome.
Chun‐Hung Liu, Guann‐Jen Chern, Fu‐Fei Hsu, Kuan‐Wei Huang, Yun‐Chieh Sung, Hsi‐Chien Huang, Jiantai Timothy Qiu, Sheng‐Kai Wang, Chu‐Chi Lin, Chien‐Hsun Wu, Han‐Chung Wu, Jia‐Yu Liu, Yunching Chen – 8 September 2017 – The anticancer efficacy of TNF‐related apoptosis‐inducing ligand (TRAIL)‐based therapy is limited because of systemic toxicity, poor bioavailability, and development of TRAIL resistance.
Chathur Acharya, James B. Wade, Andrew Fagan, Melanie White, Edith Gavis, Dinesh Ganapathy, HoChong Gilles, Douglas M. Heuman, Jasmohan S. Bajaj – 8 September 2017 – After an initial exposure, patients can develop test‐taking/learning strategies called the “test sophistication effect.” Patients with cirrhosis with prior overt hepatic encephalopathy (OHE) could have persistent learning impairments.
Andrea Schlegel, Irene Scalera, M. Thamara P. R. Perera, Marit Kalisvaart, Hynek Mergental, Darius F. Mirza, John Isaac, Paolo Muiesan – 8 September 2017 – Advanced donor age has been identified as a risk factor when combined with donor warm ischemia time (WIT), eg, in donation after circulatory death (DCD). In several countries, DCD livers older than 60 years are not considered suitable due to concerns related to poor graft function and development of ischemic cholangiopathy. In this study, we evaluate outcomes after DCD liver transplantation using grafts from donors older than 60 years.
Eung Chang Lee, Seong Hoon Kim, Jae Ryong Shim, Sang‐Jae Park – 8 September 2017 – Living donor liver transplantation (LDLT) has been reported to have high rates of hepatocellular carcinoma (HCC) recurrence compared with deceased donor liver transplantation (DDLT). This has been assumed to be due to the frequent use of small‐for‐size grafts (SFSGs) in LDLT rather than DDLT, but the relationship between graft size and prognosis remains controversial. This study aimed to clarify the effect of SFSGs on the oncologic outcomes of patients with HCC who underwent LDLT.
Xijiao Liu, Hanyu Jiang, Jie Chen, You Zhou, Zixing Huang, Bin Song – 8 September 2017 – Early detection of small hepatocellular carcinoma (HCC) lesions can improve longterm patient survival. A systematic review and meta‐analysis of the diagnostic performance of gadoxetic acid disodium (Gd‐EOB‐DTPA)–enhanced magnetic resonance imaging (MRI) and multidetector computed tomography (MDCT) was performed in diagnosing small HCCs measuring up to 2 cm (≤2 cm).
Two new HCV meds have been approved over the summer. This webinar is meant to provide an update on how these fit into current practice. We will also cover the ongoing controversy on the risk of HCC with DAA's and the recent Cochrane report on the benefits of HCV therapy.Insook Kim (Moderator) Insook Kim, PhD is a clinical pharmacology team leader for gastroenterology and hepatology products in the Office of Clinical Pharmacology at FDA.
Richard S. Finn, Andrew X. Zhu, Wigdan Farah, Jehad Almasri, Feras Zaiem, Larry J. Prokop, Mohammad Hassan Murad, Khaled Mohammed – 7 September 2017 – Hepatocellular carcinoma (HCC) is a complex disease most commonly arising in the background of chronic liver disease. In the past two decades, there has been a significant increase in our understanding of both the clinical and molecular heterogeneity of HCC. There has been a robust increase in clinical trial activity in patients with poor prognostic factors, such as macrovascular invasion and extrahepatic spread (EHS).
Keely Marshall, Junfei Jin, Carl Atkinson, Ali Alawieh, Fei Qiao, Biao Lei, Kenneth D. Chavin, Songqing He, Stephen Tomlinson – 7 September 2017 – Complement plays a role in both hepatic ischemia reperfusion (IR) injury (IRI) and liver regeneration, but it is not clear how complement is activated in either process. We investigated the role of self‐reactive immunoglobulin M (IgM) antibodies in activating complement after hepatic IR and liver resection.
Richard S. Finn, Andrew X. Zhu, Wigdan Farah, Jehad Almasri, Feras Zaiem, Larry J. Prokop, Mohammad Hassan Murad, Khaled Mohammed – 7 September 2017 – Hepatocellular carcinoma (HCC) is a complex disease most commonly arising in the background of chronic liver disease. In the past two decades, there has been a significant increase in our understanding of both the clinical and molecular heterogeneity of HCC. There has been a robust increase in clinical trial activity in patients with poor prognostic factors, such as macrovascular invasion and extrahepatic spread (EHS).