Self‐assembled liver organoids recapitulate hepatobiliary organogenesis in vitro

Dipen Vyas, Pedro M. Baptista, Matthew Brovold, Emma Moran, Brandon Gaston, Chris Booth, Michael Samuel, Anthony Atala, Shay Soker – 23 August 2017 – Several three‐dimensional cell culture systems are currently available to create liver organoids. In gneral, these systems display better physiologic and metabolic aspects of intact liver tissue compared with two‐dimensional culture systems. However, none reliably mimic human liver development, including parallel formation of hepatocyte and cholangiocyte anatomical structures.

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