Health‐related quality of life after pediatric liver transplantation: A systematic review

Arpita Parmar, Shannon Marie Vandriel, Vicky Lee Ng – 22 December 2016 – With improved survival rates after pediatric liver transplantation (LT), attention is targeting improving the health‐related quality of life (HRQOL) as an outcome metric. We conducted a systematic review of the literature to examine HRQOL after pediatric LT, focusing on assessment tools and factors associated with HRQOL. A literature search was conducted through PubMed, Web of Science, Ovid, and Google Scholar for all studies matching the eligibility criteria between January 2004 and September 2016.

Differential profile of activated regulatory T cell subsets and microRNAs in tolerant liver transplant recipients

Beatriz Revilla‐Nuin, África de Bejar, Laura Martínez‐Alarcón, José Ignacio Herrero, Carlos Manuel Martínez‐Cáceres, Pablo Ramírez, Alberto Baroja‐Mazo, José Antonio Pons – 22 December 2016 – Regulatory T cells (Tregs) play a potential role in operational tolerance in liver transplantation (LT) patients, and microRNAs (miRNAs) are known to be involved in immunological responses and tolerance.

Update on pharmacotherapies for cholestatic liver disease

Ahmad H. Ali, James H. Tabibian, Keith D. Lindor – 21 December 2016 – Cholestatic liver diseases are conditions with impaired bile formation and/or flow due to genetic, immunologic, environmental, or other causes. Unless successfully treated, this can lead to chronic liver injury and end‐stage liver disease. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) embody the most prominent adult cholestatic liver diseases with regard to incidence, morbidity, and mortality.

New therapeutic concepts in bile acid transport and signaling for management of cholestasis

Michael Trauner, Claudia Daniela Fuchs, Emina Halilbasic, Gustav Paumgartner – 20 December 2016 – The identification of the key regulators of bile acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for pharmacological therapies of cholestatic liver diseases.

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