Longterm prognosis of combined hepatocellular carcinoma‐cholangiocarcinoma following liver transplantation and resection

Dong‐Hwan Jung, Shin Hwang, Gi‐Won Song, Chul‐Soo Ahn, Deok‐Bog Moon, Ki‐Hun Kim, Tae‐Yong Ha, Gil‐Chun Park, Seung‐Mo Hong, Wan‐Jun Kim, Woo‐Hyoung Kang, Seok‐Hwan Kim, Eun Sil Yu, Sung‐Gyu Lee – 27 December 2016 – Combined hepatocellular carcinoma–cholangiocarcinoma (cHCC‐CC) is a rare disease. We investigated the clinicopathological features of cHCC‐CC and compared the longterm outcomes following liver transplantation (LT) and hepatic resection (HR). We identified 32 LT patients with cHCC‐CC through an institutional database search.

Comparison of longterm outcomes and quality of life in recipients of donation after cardiac death liver grafts with a propensity‐matched cohort

Kristopher P. Croome, David D. Lee, Dana K. Perry, Justin M. Burns, Justin H. Nguyen, Andrew P. Keaveny, C. Burcin Taner – 27 December 2016 – The use of liver grafts from donation after cardiac death (DCD) has been limited due to the increased rate of graft failure, mostly related to ischemic cholangiopathy (IC). It is our hypothesis that longterm outcomes and quality of life (QOL) similar to patients undergoing liver transplantation (LT) with donation after brain death (DBD) can be achieved.

A practical approach to nutritional screening and assessment in cirrhosis

Puneeta Tandon, Maitreyi Raman, Marina Mourtzakis, Manuela Merli – 27 December 2016 – Malnutrition is one of the most common complications of cirrhosis, associated with an increased risk of morbidity and mortality. As a potentially modifiable condition, it is of particular importance to identify malnourished patients so that nutritional therapy can be instituted. Nutrition screening and assessment are infrequently performed in patients with cirrhosis.

Defects in myosin VB are associated with a spectrum of previously undiagnosed low γ‐glutamyltransferase cholestasis

Yi‐Ling Qiu, Jing‐Yu Gong, Jia‐Yan Feng, Ren‐Xue Wang, Jun Han, Teng Liu, Yi Lu, Li‐Ting Li, Mei‐Hong Zhang, Jonathan A. Sheps, Neng‐Li Wang, Yan‐Yan Yan, Jia‐Qi Li, Lian Chen, Christoph H. Borchers, Bence Sipos, A.S. Knisely, Victor Ling, Qing‐He Xing, Jian‐She Wang – 27 December 2016 – Hereditary cholestasis in childhood and infancy with normal serum gamma‐glutamyltransferase (GGT) activity is linked to several genes. Many patients, however, remain genetically undiagnosed.

Outcomes utilizing imported liver grafts for recipients with hepatocellular carcinoma

Narendra Battula, Trevor W. Reichman, Yamah Amiri, Ian C. Carmody, Gretchen Galliano, John Seal, Emily Bugeaud, Humberto Bohorquez, David Bruce, Ari Cohen, George E. Loss – 27 December 2016 – Liver transplantation (LT) offers the best chance of survival in selected patients with hepatocellular carcinoma (HCC). Wait‐list mortality or dropout due to tumor progression can be significant, and therefore, timely transplantation is critical. Liver grafts discarded by outside organ procurement organizations are a potential source of grafts for low Model for End‐Stage Liver Disease tumor patients.

Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis

Kyle S. McCommis, Wesley T. Hodges, Elizabeth M. Brunt, Ilke Nalbantoglu, William G. McDonald, Christopher Holley, Hideji Fujiwara, Jean E. Schaffer, Jerry R. Colca, Brian N. Finck – 27 December 2016 – Diseases of the liver related to metabolic syndrome have emerged as the most common and undertreated hepatic ailments. The cause of nonalcoholic fatty liver disease is the aberrant accumulation of lipid in hepatocytes, though the mechanisms whereby this leads to hepatocyte dysfunction, death, and hepatic fibrosis are still unclear.

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